Prenatal Exposure to Polycyclic Aromatic Hydrocarbons and Birth Outcomes
Rattachement africain : cz. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Background and objectives: The impact of prenatal exposure to polycyclic aromatic hydrocarbons (PAHs) to birth outcomes as weight, length, head perimeter, placenta weight and Apgar score. Materials and Methods: Two cohorts of children born in the years 2013 and 2014 in Karvina (Northern Moravia, N=144) and Ceske Budejovice (Southern Bohemia, N=198) were studied for the relationship between prenatal exposure to PAHs and growth parameters up to two years of age. PAHs exposure was evaluated according to concentration of benzo[a]pyrene (B[a]P) in polluted air and monohydroxylated PAH metabolites (OH-PAHs) in urine of newborns and their mothers. Data on growth parameters were obtained from pediatric questionnaires up to 24 months. Results: Concentrations of B[a]P were significantly higher in Karvina (p<0.001). OH-PAH metabolites were significantly higher in the mother´s as well as in the newborn’ s urine in Karvina. The length was shorter in newborns in Karvina at birth (p<0.001), but this difference was straightened out during next 3 to 24 months. Birth weight at the delivery did not differ between newborns in Karvina and Ceske Budejovice. Newborns in both locations significantly decreased their weight gain between birth and 3 months after delivery. OH-PAHs metabolites in mother’s or newborn’s urine did not affect birth weight. Top 25% values of concentrations of 2-OH-FLUO, 1-OH-NAP, 2-OH-NAP, 1-OH-PHEN, 2-OH-PHEN, 3-OH-PHEN, 4-OH-PHEN and the sum of all-OH-PAHs higher than median in the newborn´s urine decreased their length. 2-OH-PHEN top 25% of concentrations in the newborn´s urine decreased their head perimeter, 2-OH-FLUO, 1-OH-NAP, 2-OH-NAP, 1-OH-PHEN, 2-OH-PHEN, 3-OH-PHEN, 4-OH-PHEN, 9-OH-PHEN, 1-OH-PYR, and all-OH-PAHs decreased placenta weight; 2-OH-FLUO, 1-OH-NAP, 2-OH-NAP, 1-OH-PHEN, 2-OH-PHEN, 3-OH-PHEN, 4-OH-PHEN, and all-OH-PAHs decreased Apgar 5´. Conclusions: We observed that higher concentration of PAHs determined as OH-PAHs metabolites in newborn´s urine decreased their length, head perimeter, placenta weight, and Apgar 5´, but did not affect birth weight.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Prenatal Exposure to Polycyclic Aromatic Hydrocarbons and Birth Outcomes
- Date Crossref
- 03/10/2022
- Éditeur
- MDPI AG
- Type
- posted-content
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Institute of Clinical and Experimental Medicine pays non établi dans la noticeÉtablissement de santé
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Czech Academy of Sciences pays non établi dans la noticeStructure de recherche
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University of South Bohemia in České Budějovice pays non établi dans la noticeUniversité ou école supérieure
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Nemocnice České Budějovice pays non établi dans la noticeÉtablissement de santé
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University of Chemistry and Technology pays non établi dans la noticeUniversité ou école supérieure
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Institute of Experimental Medicine CAS pays non établi dans la noticeStructure de recherche
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Faculty of Health and Social Sciences pays non établi dans la noticeUniversité ou école supérieure
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Hospital Ceske Budejovice pays non établi dans la noticeÉtablissement de santé
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Faculty of Food and Biochemical Technology pays non établi dans la noticeUniversité ou école supérieure
Institute of Clinical and Experimental Medicine, Czech Academy of Sciences et University of South Bohemia in České Budějovice, avec 6 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.