Accès ouvert déclaré
2020
article
Integrated Molecular Characterization of Uterine Carcinosarcoma
Jaegil Kim, Hui Shen, Robert Hoffmann, Wei Zhang, Angela Tam, Steven J.M. Jones, Jiashan Zhang, Vonn Walter, Mutch David, Chen Wang, Daniel J. Weisenberger, Andrew D. Cherniack, John N. Weinstein, Sean C. Dowdy, Matthew G. Soloway, Shiyun Ling, Rehan Akbani, Helga B. Salvesen, Manaswi Gupta, Carrie Sougnez, Corbin D. Jones, Tom Bodenheimer, Roel G.W. Verhaak, A. Gordon Robertson, Liming Yang, Noreen Dhalla, Gad Getz, Ignaty Leshchiner, Tina Wong, Jeffrey Roach, Erik Zmuda, Peter W. Laird, Phillip H. Lai, Michael S. Lawrence, Jean C. Zenklusen, David Haussler, Chip Stewart, Donghui Tan, Andrew J. Mungall, Ina Felau, Rashi Naresh, Nina Thiessen, Narciso Olvera, Jacqueline E. Schein, Jia Liu, Denise Brooks, Katherine A. Hoadley, Piotr A. Mieczkowski, Cyriac Kandoth, Ye Wu, Nilsa C. Ramirez, W. Kimryn Rathmell, Boris Winterhoff, Lisa Wise, Martin L. Ferguson, Rupa S. Kanchi, Julie M. Gastier-Foster, David I. Heiman, Eric S. Lander, Scott Frazer, Marco A. Marra, Robert A. Holt, Julian M. Hess, Michael S. Noble, Sudha Chudamani, Pei Lin, Rebecca Carlsen, Stephen B. Baylin, Saianand Balu, Russell R. Broaddus, Kristian Cibulskis, Eric Chuah, Yan Shi, Juliann Shih, Faina Bogomolniy, Hailei Zhang, Heidi J. Sofia, Payal Sipahimalani, Rosemary E. Zuna, Carolyn M. Hutter, Douglas A. Levine, Amie Radenbaugh, Amanda von Bismarck, Dennis T. Maglinte, Robert A. Soslow, Gordon Saksena, Michael Mayo, J. Todd Auman, Raju Kucherlapati, Mei Huang, Kane Tse, Yunhu Wan, Adrian Ally, Reanne Bowlby, Mark Gerken, Jill Tseng, Melissa Cline, Umadevi Veluvolu, Amy H. Perou, Lisle E. Mose, Tara Skelly, Shaowu Meng, Kristen M. Leraas, Jingchun Zhu, Matthew Meyerson, Todd Pihl, Rameen Beroukhim, John A. Demchok, Fanny Dao, Roy Tarnuzzer, Tara M. Lichtenberg, Jessica Frick, Margi Sheth, Jay Bowen, Alan P. Hoyle, Xin Hu, Doug Voet, Gordon B. Mills, D. Neil Hayes, Yuexin Liu, Darlene Lee, Sarah E. Kerr, Laxmi Lolla, Matthew D. Wilkerson, Richard A. Moore, Yiling Lu, Juok Cho, Lori Boice, Charlie Sun, Leigh B. Thorne, Yussanne Ma, Steven E. Schumacher, Miruna Balasundaram, Joel S. Parker, Sara Sadeghi, Gordon L. Robertson, Wenbin Liu, Charles M. Perou, Nils Gehlenborg, Janae V. Simons, Bradley A. Murray, Karen Mungall, Stacey Gabriel, David Van Den Berg
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Rattachement africain : us.
Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
SummaryWe performed genomic, epigenomic, transcriptomic, and proteomic characterizations of uterine carcinosarcomas (UCSs). Cohort samples had extensive copy-number alterations and highly recurrent somatic mutations. Frequent mutations were found in TP53, PTEN, PIK3CA, PPP2R1A, FBXW7, and KRAS, similar to endometrioid and serous uterine carcinomas. Transcriptome sequencing identified a strong epithelial-to-mesenchymal transition (EMT) gene signature in a subset of cases that was attributable to epigenetic alterations at microRNA promoters. The range of EMT scores in UCS was the largest among all tumor types studied via The Cancer Genome Atlas. UCSs shared proteomic features with gynecologic carcinomas and sarcomas with intermediate EMT features. Multiple somatic mutations and copy-number alterations in genes that are therapeutic targets were identified.
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Les sujets associés
Uterine Myomas and Treatments