Accès ouvert déclaré
2021
review
Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index
Sang Lee, Jong‐Young Lee, Shengxu Li, Jyh Ming J.immy Juang, Terri L. Young, Treva Rice, Lixuan Gui, Jeannette Lee, Wei Zheng, Eric H. Kim, Yasuharu Tabara, Themistocles L. Assimes, Toru Nabika, Ying Wu, Dong‐Hoon Shin, Rick T.h. Ong, Jirong Long, Satoshi Umemura, Yu Tang Gao, Bu Tian Ji, Wu Chen, Jian J.un Liu, Tatsuhiko Tsunoda, Wen Jane Lee, Xiaobo Yang, Yii Der I. Chen, Huai‐Dong Song, Frank B. Hu, Lin Xu, Min J.in Go, Toshihiro Tanaka, Young Ho Lee, Zengnan Mo, Byung Yeol Chun, James E. Hixson, Gan Wei, Naoyuki Takashima, Qiuyin Cai, Bo Y.oul Choi, Juyoung Lee, Min Ho Shin, Linda S. Adair, Meian He, Tin Aung, Tangchun Wu, Xiao Ou Shu, Mi K.yung Kim, Tetsuro Miki, Tien Y.in Wong, Michiaki Kubo, Yoon Shin Cho, Chao A.gnes Hsiung, Ryoichi Takayanagi, Jane Z. Kuo, Ken Yamamoto, Xingyi Guo, Xueya Zhou, I. Chien Wu, Karen L. Mohlke, I‐Te Lee, Dongfeng Gu, Young J.in Kim, Bong Jo Kim, E. Shyong Tai, Masato Isono, Aihua Tan, Yong Xiang, Tzung Dao Wang, Daehee Kang, Norihiro Kato, Wei Y.en Lim, Yukinori Okada, Jer Yuarn Wu, Kent D. Taylor, Jun Liang, Huaixing Li, Yi Zhang, Fuu Jen Tsai, Wei Lü, Minoru Isomura, Xiuqing Guo, Yong Gao, Ling Lü, Takayoshi Ohkubo, Jerome I. Rotter, Jiajun Shi, Ryan Delahanty, Bok Ghee Han, Jiang He, Lu Qi, Rajkumar Dorajoo, Dingliang Zhu, Wanqing Wen, Wayne H.uey Herng Sheu, Fumihiko Takeuchi, Chii Min Hwu, Myeong‐Chan Cho, Joo Yeon Hwang, Ching Chu Chen, Wei Yen Lim, Xueling Sim, Matthew Allison, Koichi Akiyama, Jie Yao, Mark Seielstad, Xiaofei Yan, Soonil Kwon, Devin Absher, Chien-Hsiun Chen
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Le résumé fourni par la source
Recent genetic association studies have identified 55 genetic loci associated with obesity or body mass index (BMI). The vast majority, 51 loci, however, were identified in European-ancestry populations. We conducted a meta-analysis of associations between BMI and ∼2.5 million genotyped or imputed single nucleotide polymorphisms among 86 757 individuals of Asian ancestry, followed by in silico and de novo replication among 7488–47 352 additional Asian-ancestry individuals. We identified four novel BMI-associated loci near the KCNQ1 (rs2237892, P = 9.29 × 10−13), ALDH2/MYL2 (rs671, P = 3.40 × 10−11; rs12229654, P = 4.56 × 10−9), ITIH4 (rs2535633, P = 1.77 × 10−10) and NT5C2 (rs11191580, P = 3.83 × 10−8) genes. The association of BMI with rs2237892, rs671 and rs12229654 was significantly stronger among men than among women. Of the 51 BMI-associated loci initially identified in European-ancestry populations, we confirmed eight loci at the genome-wide significance level (P < 5.0 × 10−8) and an additional 14 at P < 1.0 × 10−3 with the same direction of effect as reported previously. Findings from this analysis expand our knowledge of the genetic basis of obesity.
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Les sujets associés
Genetic Associations and EpidemiologyNutrition, Genetics, and DiseaseFolate and B Vitamins Research