Potential Modulation of Inflammation by Probiotic and Omega-3 Supplementation in Elderly with Chronic Low-Grade Inflammation—A Randomized, Placebo-Controlled Trial
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Le résumé fourni par la source
Probiotic and omega-3 supplements have been shown to reduce inflammation, and dual supplementation may have synergistic health effects. We investigated if the novel combination of a multi-strain probiotic (containing B. lactis Bi-07, L. paracasei Lpc-37, L. acidophilus NCFM, and B. lactis Bl-04) alongside omega-3 supplements reduces low-grade inflammation as measured by high-sensitivity C-reactive protein (hs-CRP) in elderly participants in a proof-of-concept, randomized, placebo-controlled, parallel study (NCT04126330). In this case, 76 community-dwelling elderly participants (median: 71.0 years; IQR: 68.0–73.8) underwent an intervention with the dual supplement (n = 37) or placebo (n = 39) for eight weeks. In addition to hs-CRP, cytokine levels and intestinal permeability were also assessed at baseline and after the eight-week intervention. No significant difference was seen for hs-CRP between the dual supplement group and placebo. However, interestingly, supplementation did result in significant increases in the level of the anti-inflammatory marker IL-10. In addition, dual supplementation increased levels of valeric acid, further suggesting the potential of the supplements in reducing inflammation and conferring health benefits. Together, the results suggest that probiotic and omega-3 dual supplementation exerts modest effects on inflammation and may have potential use as a non-pharmacological treatment for low-grade inflammation in the elderly.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Potential Modulation of Inflammation by Probiotic and Omega-3 Supplementation in Elderly with Chronic Low-Grade Inflammation—A Randomized, Placebo-Controlled Trial
- Date Crossref
- 27/09/2022
- Éditeur
- MDPI AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Linköping University Department of Biomedical and Clinical Sciences pays non établi dans la noticeUniversité ou école supérieure
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Örebro University Food and Health Programme pays non établi dans la noticeUniversité ou école supérieure
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University of Hohenheim Department of Nutritional Medicine and Prevention pays non établi dans la noticeUniversité ou école supérieure
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Wageningen University & Research Department of Agrotechnology and Food Sciences pays non établi dans la noticeUniversité ou école supérieure
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School of Medical Sciences Nutrition-Gut-Brain Interactions Research Centre pays non établi dans la noticeUniversité ou école supérieure
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GSK Consumer Healthcare ApS pays non établi dans la noticeInstitution
Department of Biomedical and Clinical Sciences — Linköping University, Food and Health Programme — Örebro University et Department of Nutritional Medicine and Prevention — University of Hohenheim, avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.