Childhood exposure to per- and polyfluoroalkyl substances and neurodevelopment in the CHARGE case-control study
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Le résumé fourni par la source
BACKGROUND: Per- and polyfluoroalkyl substances (PFAS) are shown to have neurotoxic effects on animals, but epidemiological evidence for associations between childhood PFAS exposure and neurodevelopment is inconclusive. We examined if childhood PFAS concentrations are associated with a diagnosis of autism spectrum disorder (ASD), developmental delay (DD), and other early concerns (OEC) in development. METHODS: We included 551 children 2-5 years old from the CHildhood Autism Risks from Genetics and Environment (CHARGE) case-control study. Children were clinically diagnosed and classified as having ASD, DD, OEC, and typical development (TD). Fourteen PFAS were quantified in child serum samples collected when diagnostic assessments were performed. We used multinomial logistic regression models to investigate the cross-sectional associations of individual PFAS concentrations with neurodevelopmental outcomes and weighted quantile sum (WQS) regression models with repeated holdout validation to investigate the associations with PFAS mixtures. RESULTS: Childhood perfluorooctanoic acid (PFOA) was associated with increased odds of ASD (odds ratio [OR] per ln ng/mL increase: 1.99, 95% confidence interval [CI]: 1.20, 3.29) and DD (OR: 2.16, 95% CI: 1.21, 3.84) versus TD. Perfluoroheptanoic acid (PFHpA) was associated with increased odds of ASD (OR: 1.61, 95% CI: 1.21, 2.13). However, perfluroundecanoic acid (PFUnDA) was associated with decreased odds of ASD (OR: 0.43, 95% CI: 0.26, 0.69). From mixture analyses, the WQS index was associated with increased odds of ASD (average OR: 1.57, 5th and 95th percentile: 1.16, 2.13). Child's sex and homeownership modified associations of perfluorodecanoic acid (PFDA) with DD and ASD, respectively. CONCLUSIONS: In this case-control study, childhood PFOA, PFHpA, and a PFAS mixture was associated with increased odds of ASD, while PFUnDA was associated with decreased odds of ASD. Because we used concurrent measurements of PFAS, our results do not imply causal relationships and thus need to be interpreted with caution.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Childhood exposure to per- and polyfluoroalkyl substances and neurodevelopment in the CHARGE case-control study
- Date Crossref
- 01/12/2022
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of California Department of Public Health Sciences pays non établi dans la noticeUniversité ou école supérieure
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Baylor University Department of Environmental Science pays non établi dans la noticeUniversité ou école supérieure
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Albany State University pays non établi dans la noticeUniversité ou école supérieure
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New York State Department of Health pays non établi dans la noticeOrganisme public
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Wadsworth Center pays non établi dans la noticeStructure de recherche
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University at Albany Department of Environmental Health Sciences pays non établi dans la noticeUniversité ou école supérieure
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New York University Department of Pediatrics and Department of Environmental Medicine pays non établi dans la noticeUniversité ou école supérieure
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Icahn School of Medicine at Mount Sinai Department of Environmental Medicine and Public Health pays non établi dans la noticeUniversité ou école supérieure
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University of California Davis Medical Center pays non établi dans la noticeÉtablissement de santé
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Division of Environmental Health Sciences pays non établi dans la noticeInstitution
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UC Davis MIND (Medical Investigations of Neurodevelopmental Disorders) Institute pays non établi dans la noticeStructure de recherche
Department of Public Health Sciences — University of California, Department of Environmental Science — Baylor University et Albany State University, avec 8 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.