Reference intervals for erythrocyte parameters and hemoglobin electrophoresis parameters for young children in Guangxi
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Le résumé fourni par la source
BACKGROUND: Erythrocyte parameter analysis is the important means for diagnosis and treatment of hematological diseases, which are essential for screening of thalassemia in southern China combined with hemoglobin electrophoresis analysis. But little is known regarding the reference intervals (RIs) in healthy pediatrics in these two areas. METHODS: 95% RIs of erythrocyte parameters were calculated from 853 healthy preschoolers, aged from 1 days to <6 years, according to the C28-A3C guidelines of the Institute of Clinical and Laboratory Standards. To express the magnitude of sex and age variation, standard deviation ratio (SDR) was calculated using ANOVA. Concurrently, we selected 3814 thalassemia carriers as carriers group and drew receiver operating characteristic (ROC) curves to establish the optimal cut-off values of hemoglobin electrophoresis parameters, which were used as the upper/lower limits of RIs to efficiently screen thalassemia. RESULTS: below .4. The optimal cut-off value of Hemoglobin A2 (Hb A2) in the four subgroups was <7.8% (Hb A), 2.3%-3.2%, 2.5%-3.6% and 2.6%-3.6%, respectively. CONCLUSION: In this study, the establishment of RIs improved the diagnostic efficiency of hematological disease (especially thalassaemia) for children in Guangxi. It provides reliable hematological references for the identification and diagnosis, treatment monitoring, and health screening of children's clinical diseases.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Reference intervals for erythrocyte parameters and hemoglobin electrophoresis parameters for young children in Guangxi
- Date Crossref
- 05/09/2022
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Guangxi Maternal and Child Health Hospital pays non établi dans la noticeÉtablissement de santé
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Guangzhou Medical University Reproductive Medical Center pays non établi dans la noticeUniversité ou école supérieure
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Affiliated Hospital of Youjiang Medical University for Nationalities pays non établi dans la noticeÉtablissement de santé
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Southern Medical University pays non établi dans la noticeUniversité ou école supérieure
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Genetic and Metabolic Central Laboratory pays non établi dans la noticeStructure de recherche
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Youjiang Medical University for Nationalities Baise Guangxi People's Republic of China pays non établi dans la noticeUniversité ou école supérieure
Guangxi Maternal and Child Health Hospital, Reproductive Medical Center — Guangzhou Medical University et Affiliated Hospital of Youjiang Medical University for Nationalities, avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.