Intensity Of Depression Symptoms Is Negatively Associated With Catalase Activity In Master Athletes

Résumé fourni par la source

BACKGROUND: Depression is among the most prevalent mental health problems during aging. Oxidative stress is involved in its pathophysiology, while a better antioxidant defense seems to attenuate the intensity of symptoms. Lifelong training, like that of master athletes, has been associated with improved antioxidant defense. However, no studies compared depression symptoms of master athletes to untrained peers, nor verified the possible relationship between depression scores and a marker of antioxidant defense, such as catalase (CAT) activity. PURPOSE: To compare and verify possible associations between CAT and the intensity of depression symptoms in middle-aged master athletes and untrained peers. METHODS: Participants were master athletes from Sprints (MS, n = 24, 50.37 ± 6.23 yr) and Endurance Running (ER, n = 11, 51.30 ± 9.21 yr), besides untrained control groups of middle-aged (CO, n = 13, 47.16 ± 8.70 yr) and young individuals (YU, n = 15, 23.70 ± 4.02 yr). Blood samples were collected for CAT measures using commercial kits, and Beck Depression Inventory was applied to measure depression symptoms. ANOVA and Pearson's Correlation Coefficient were applied, with a significance level of p ≤ 0.05. RESULTS: The CAT of MS and YU [768.6 U·μL-1 ± 168.6 U·μL-1 and 729.9 U·μL-1 ± 186.9 U·μL-1] were higher than CO and ER [410.3 U·μL-1 ± 67.24 U·μL-1 and 528.8 U·μL-1 ± 103.2 U·μL-1 (p < 0.0001)]. MS had lower intensity of depression symptoms compared to the YU and ER [2.86 ± 2.81 vs 10.36 ± 5.79 vs 7.20 ± 5.20 (p = 0.0002)], but there was no difference in relation to CO [5.00 ± 2.25]. Negative correlation was found between CAT and intensity of depression symptoms for the entire group of master athletes [r = -0.4486 (p = 0.0100)]. CONCLUSION: Master sprinters presented the lowest intensity of depression symptoms, with CAT being higher than CO and ER. CAT was negatively associated with intensity of depression symptoms, suggesting that training model of master sprinters may be an effective strategy in increasing CAT and reducing depressive symptoms.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.