Characteristics of people with epilepsy in three Eastern African countries – a pooled analysis
Rattachement africain : de, Ouganda, no, Tanzanie, at, Malawi, gb. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND: Epilepsy is one of the most common neurological disorders worldwide. Yet, its treatment gap is large in some areas and especially in sub-Saharan Africa data on clinical, radiological and semiological characteristics, as well as on treatment of persons with epilepsy (PWE) are still scarce. METHODS: We pooled data from four cross-sectional studies on epilepsy in eastern Africa. Two studies from Malawi and Uganda were community-based; two studies in Tanzania (urban Dar es Salaam and rural Haydom) were hospital-based. Clinical characteristics of PWE were assessed by the same questionnaire. Additionally, data on treatment were collected and computed tomography (CT) scans were performed. RESULTS: Overall, 1179 PWE were included in our analysis (581 (49.3%) female, median age 22 years (IQR 15-32 years)). Up to 25% of the patients had focal onset seizures. Those showed a higher rate of remarkable CT scan findings, with especially post-ischaemic and neurocysticercosis-associated lesions, compared to PWE with generalized onset seizures (35.1% vs. 20%). The majority of the patients experienced tonic-clonic seizures (70-85%). Only 67-78% of PWE received anti-seizure medication (ASM) treatment in the community-based studies, mostly monotherapy with phenobarbital, phenytoin or carbamazepine. Yet, underdosage was frequent and a large proportion of PWE received alternative non-ASM treatment consisting of herbal treatment (up to 83%) and/or scarification (up to 20%). CONCLUSIONS: Epilepsy is common in sub-Saharan Africa, often caused by neurocysticercosis or ischaemic strokes. PWE suffer from high seizure rates and subsequent injuries, as well as from socio-economic consequences due to insufficient ASM treatment. This pooled analysis illustrates the need for structural programmes for adequate identification, education, assessment and treatment of PWE in sub-Saharan Africa.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Characteristics of people with epilepsy in three Eastern African countries – a pooled analysis
- Date Crossref
- 26/08/2022
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Technical University of Munich pays non établi dans la noticeUniversité ou école supérieure
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Ministry of Health Kampala, Ouganda (code pays fourni par la source)Organisme public
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University of Oslo Institute of Health and Society pays non établi dans la noticeUniversité ou école supérieure
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Universitätsklinikum Erlangen pays non établi dans la noticeÉtablissement de santé
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Mbeya University of Science and Technology Mbeya, Tanzanie (code pays fourni par la source)Université ou école supérieure
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National Institute for Medical Research Dar es Salaam, Tanzanie (code pays fourni par la source)Structure de recherche
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Muhimbili University of Health and Allied Sciences Department of Neurology Dar es Salaam, Tanzanie (code pays fourni par la source)Université ou école supérieure
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University of Tübingen pays non établi dans la noticeUniversité ou école supérieure
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Gulu University Gulu University, Ouganda (code pays fourni par la source)Université ou école supérieure
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Innsbruck Medical University pays non établi dans la noticeUniversité ou école supérieure
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Universität Innsbruck pays non établi dans la noticeUniversité ou école supérieure
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Christian Health Association of Malawi Malawi (code pays fourni par la source)Institution
Technical University of Munich, Ministry of Health (Kampala, Ouganda) et Institute of Health and Society — University of Oslo, avec 9 autres affiliations. Pays d’affiliation : Ouganda, Tanzanie, Malawi.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.