Reduced cortical cerebral blood flow in antipsychotic-free first-episode psychosis and relationship to treatment response
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Le résumé fourni par la source
Abstract Background Altered cerebral blood flow (CBF) has been found in people at risk for psychosis, with first-episode psychosis (FEP) and with chronic schizophrenia (SCZ). Studies using arterial spin labelling (ASL) have shown reduction of cortical CBF and increased subcortical CBF in SCZ. Previous studies have investigated CBF using ASL in FEP, reporting increased CBF in striatum and reduced CBF in frontal cortex. However, as these people were taking antipsychotics, it is unclear whether these changes are related to the disorder or antipsychotic treatment and how they relate to treatment response. Methods We examined CBF in FEP free from antipsychotic medication ( N = 21), compared to healthy controls ( N = 22). Both absolute and relative-to-global CBF were assessed. We also investigated the association between baseline CBF and treatment response in a partially nested follow-up study ( N = 14). Results There was significantly lower absolute CBF in frontal cortex (Cohen's d = 0.84, p = 0.009) and no differences in striatum or hippocampus. Whole brain voxel-wise analysis revealed widespread cortical reductions in absolute CBF in large cortical clusters that encompassed occipital, parietal and frontal cortices (Threshold-Free Cluster Enhancement (TFCE)-corrected <0.05). No differences were found in relative-to-global CBF in the selected region of interests and in voxel-wise analysis. Relative-to-global frontal CBF was correlated with percentage change in total Positive and Negative Syndrome Scale after antipsychotic treatment ( r = 0.67, p = 0.008). Conclusions These results show lower cortical absolute perfusion in FEP prior to starting antipsychotic treatment and suggest relative-to-global frontal CBF as assessed with magnetic resonance imaging could potentially serve as a biomarker for antipsychotic response.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Reduced cortical cerebral blood flow in antipsychotic-free first-episode psychosis and relationship to treatment response
- Date Crossref
- 25/08/2022
- Éditeur
- Cambridge University Press (CUP)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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King's College London Department of Neuroimaging pays non établi dans la noticeUniversité ou école supérieure
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Azienda Universitaria Ospedaliera Consorziale - Policlinico Bari pays non établi dans la noticeÉtablissement de santé
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South London and Maudsley NHS Foundation Trust pays non établi dans la noticeÉtablissement de santé
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Hammersmith Hospital pays non établi dans la noticeÉtablissement de santé
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MRC London Institute of Medical Sciences pays non établi dans la noticeStructure de recherche
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Imperial College London pays non établi dans la noticeUniversité ou école supérieure
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Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari pays non établi dans la noticeÉtablissement de santé
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Early Intervention Psychosis Clinical Academic Group pays non établi dans la noticeÉtablissement de santé
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Faculty of Medicine pays non établi dans la noticeUniversité ou école supérieure
Department of Neuroimaging — King's College London, Azienda Universitaria Ospedaliera Consorziale - Policlinico Bari et South London and Maudsley NHS Foundation Trust, avec 6 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.