Accès ouvert déclaré 2022 article

SARS-CoV-2 Outbreak Dynamics in an Isolated US Military Recruit Training Center With Rigorous Prevention Measures

Rhonda A. Lizewski, Rachel S. G. Sealfon, Sang Woo Park, Gregory R. Smith, Chad K. Porter, Ana Silvia Gonzalez-Reiche, Yongchao Ge, Clare M. Miller, Carl W. Goforth, Hanna Pinças, Michael S. Termini, Irene Ramos, Venugopalan D. Nair, Stephen E. Lizewski, Hala Hathlool Alshammary, Regina Z. Cer, Hua‐Wei Chen, Mary‐Catherine George, Catherine E. Arnold, Lindsay A. Glang, Kyle A. Long, Francisco Malagón, Jan J. Marayag, Edgar Nunez, Gregory K. Rice, Ernesto Santa Ana, Megan A. Schilling, Darci R. Smith, Victor A. Sugiharto, Peifang Sun, Adriana van de Guchte, Zenab Khan, Jayeeta Dutta, Sindhu Vangeti, Logan J. Voegtly, Dawn L. Weir, Charlotte Jessica E. Metcalf, Olga G. Troyanskaya, Kimberly A. Bishop‐Lilly, Bryan Thomas Grenfell, Harm van Bakel, Andrew G. Letizia, Stuart C. Sealfon

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8Institutions déclarées

2Pays d’affiliation déclarés

Rattachement africain : pe, us. Niveau de preuve : code pays fourni par la source.

Le résumé fourni par la source

BACKGROUND: Marine recruits training at Parris Island experienced an unexpectedly high rate of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, despite preventive measures including a supervised, 2-week, pre-entry quarantine. We characterize SARS-CoV-2 transmission in this cohort. METHODS: Between May and November 2020, we monitored 2,469 unvaccinated, mostly male, Marine recruits prospectively during basic training. If participants tested negative for SARS-CoV-2 by quantitative polymerase chain reaction (qPCR) at the end of quarantine, they were transferred to the training site in segregated companies and underwent biweekly testing for 6 weeks. We assessed the effects of coronavirus disease 2019 (COVID-19) prevention measures on other respiratory infections with passive surveillance data, performed phylogenetic analysis, and modeled transmission dynamics and testing regimens. RESULTS: Preventive measures were associated with drastically lower rates of other respiratory illnesses. However, among the trainees, 1,107 (44.8%) tested SARS-CoV-2-positive, with either mild or no symptoms. Phylogenetic analysis of viral genomes from 580 participants revealed that all cases but one were linked to five independent introductions, each characterized by accumulation of mutations across and within companies, and similar viral isolates in individuals from the same company. Variation in company transmission rates (mean reproduction number R 0 ; 5.5 [95% confidence interval [CI], 5.0, 6.1]) could be accounted for by multiple initial cases within a company and superspreader events. Simulations indicate that frequent rapid-report testing with case isolation may minimize outbreaks. CONCLUSIONS: Transmission of wild-type SARS-CoV-2 among Marine recruits was approximately twice that seen in the community. Insights from SARS-CoV-2 outbreak dynamics and mutations spread in a remote, congregate setting may inform effective mitigation strategies.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.

Le contrôle bibliographique ouvert

DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.

Titre Crossref: SARS-CoV-2 Outbreak Dynamics in an Isolated US Military Recruit Training Center With Rigorous Prevention Measures
Date Crossref: 05/08/2022
Éditeur: Ovid Technologies (Wolters Kluwer Health)
Type: journal-article

Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.

Où se fait cette recherche

United States Naval Medical Research Unit SOUTH pays non établi dans la notice
Établissement de santé
Simons Foundation pays non établi dans la notice
Organisation à but non lucratif
Princeton University Department of Ecology and Evolutionary Biology pays non établi dans la notice
Université ou école supérieure
Icahn School of Medicine at Mount Sinai Department of Neurology pays non établi dans la notice
Université ou école supérieure
Naval Medical Research Command pays non établi dans la notice
Structure de recherche
Henry M. Jackson Foundation pays non établi dans la notice
Organisation à but non lucratif
Defense Threat Reduction Agency pays non établi dans la notice
Organisme public
Leidos (United States) pays non établi dans la notice
Entreprise
Naval Medical Research Unit SIX pays non établi dans la notice
Structure de recherche
Flatiron Institute Center for Computational Biology pays non établi dans la notice
Structure de recherche
Naval Medical Research Center Biological Defense Research Directorate pays non établi dans la notice
Structure de recherche
Navy Medicine Readiness and Training Command Beaufort pays non établi dans la notice
Institution

United States Naval Medical Research Unit SOUTH, Simons Foundation et Department of Ecology and Evolutionary Biology — Princeton University, avec 9 autres affiliations.

Une affiliation ne permet pas de déduire la nationalité d’un auteur.

Les sujets associés

COVID-19 epidemiological studiesSARS-CoV-2 detection and testingSARS-CoV-2 and COVID-19 Research

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