Anti-FHL1 autoantibodies in juvenile myositis are associated with anti-Ro52 autoantibodies but not with severe disease features
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Le résumé fourni par la source
OBJECTIVES: Four-and-a-half LIM domains 1 (FHL1) is a muscle-specific protein. Autoantibodies against FHL1 were recently discovered in adults with idiopathic inflammatory myopathies (IIMs) and were found to be associated with clinical features and outcomes indicative of increased disease severity. Anti-FHL1 autoantibodies have not been described in children. Here, the prevalence and clinical features associated with anti-FHL1 autoantibodies were examined in a large North American cohort of juvenile patients with IIM. METHODS: Sera from 338 juvenile IIM patients and 91 juvenile healthy controls were screened for anti-FHL1 autoantibodies by ELISA. Clinical characteristics and HLA alleles of those with and without anti-FHL1 autoantibodies were compared among those with juvenile IIM. RESULTS: Anti-FHL1 autoantibodies were present in 10.9% of juvenile IIM patients and 1.1% of controls. The frequency of anti-FHL1 autoantibodies among clinical and serologic subgroups did not differ. A higher percentage of Asian patients had anti-FHL1 autoantibodies (11% vs 0.7%; P = 0.002). Myositis-associated autoantibodies (MAAs) [odds ratio (OR) 2.09 (CI 1.03, 4.32)], anti-Ro52 autoantibodies specifically [OR 4.17 (CI 1.83, 9.37)] and V-sign rash [OR 2.59 (CI 1.22, 5.40)] were associated with anti-FHL1 autoantibodies. There were no differences in other features or markers of disease severity. No HLA associations with anti-FHL1 autoantibodies in Caucasian myositis patients were identified. CONCLUSION: Anti-FHL1 autoantibodies are present in ∼11% of juvenile IIM patients and commonly co-occur with MAAs, including anti-Ro52 autoantibodies. In contrast to adult IIM, anti-FHL1 autoantibodies in juvenile myositis are associated with V-sign rash but not with other distinctive clinical features or worse outcomes.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Anti-FHL1 autoantibodies in juvenile myositis are associated with anti-Ro52 autoantibodies but not with severe disease features
- Date Crossref
- 12/08/2022
- Éditeur
- Oxford University Press (OUP)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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National Institutes of Health pays non établi dans la noticeOrganisme public
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National Institute of Arthritis and Musculoskeletal and Skin Diseases pays non établi dans la noticeStructure de recherche
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Medical College of Wisconsin Department of Pediatrics pays non établi dans la noticeUniversité ou école supérieure
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Karolinska University Hospital Karolinska Institutet pays non établi dans la noticeÉtablissement de santé
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Karolinska Institutet Department of Medicine pays non établi dans la noticeUniversité ou école supérieure
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Johns Hopkins University Department of Neurology pays non établi dans la noticeUniversité ou école supérieure
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Johns Hopkins Medicine pays non établi dans la noticeÉtablissement de santé
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National Institute of Environmental Health Sciences Environmental Autoimmunity Group pays non établi dans la noticeStructure de recherche
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National Institutes of Health Clinical Center pays non établi dans la noticeÉtablissement de santé
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Oklahoma Medical Research Foundation pays non établi dans la noticeOrganisation à but non lucratif
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University of Oklahoma Health Sciences Center Veteran's Affairs Medical Center pays non établi dans la noticeÉtablissement de santé
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Laboratory of Muscle Stem Cells and Gene Regulation Muscle Disease Unit pays non établi dans la noticeStructure de recherche
National Institutes of Health, National Institute of Arthritis and Musculoskeletal and Skin Diseases et Department of Pediatrics — Medical College of Wisconsin, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.