Priority age targets for COVID-19 vaccination in Ethiopia under limited vaccine supply
Rattachement africain : it, us. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Abstract Background The worldwide inequitable access to vaccination claims for a re-assessment of policies that could minimize the COVID-19 burden in low-income countries. An illustrative example is what occurred in Ethiopia, where nine months after the launch of the national vaccination program in March 2021, only 3% of the population received two doses of COVID-19 vaccine. In the meantime, a new wave of cases caused by the emergence of Delta variant of SARS-CoV-2 was observed between July and November 2021. Methods We used a SARS-CoV-2 transmission model to estimate the level of immunity accrued before the launch of vaccination in the Southwest Shewa Zone (SWSZ) and to evaluate the impact of alternative age priority vaccination targets in a context of limited vaccine supply. The model was informed with available epidemiological evidence and detailed contact data collected across different socio-demographic settings. Results We found that, during the first year of the pandemic, 46.1-58.7% of SARS-CoV-2 infections and 24.9-48% of critical cases occurred in SWSZ were likely associated with infectors under 30 years of age. During the Delta wave, the contribution of this age group in causing critical cases was estimated to increase to 66.7-70.6%. However, our findings suggest that, when considering the vaccine product available at the time (ChAdOx1 nCoV-19; 65% efficacy against infection after 2 doses), prioritizing the elderly for vaccination remained the best strategy to minimize the disease burden caused by Delta, irrespectively to the number of available doses. Vaccination of all individuals aged 50□years or older would have averted 40 (95%CI: 18-60), 90 (95%CI: 61-111), and 62 (95%CI: 21-108) critical cases per 100,000 residents in urban, rural, and remote areas, respectively. Vaccination of all individuals aged 30□years or more would have averted an average of 86-152 critical cases per 100,000 individuals, depending on the setting considered. Conclusions Despite infections among children and young adults likely caused 70% of critical cases during the Delta wave in SWSZ, most vulnerable ages should remain a key priority target for vaccination against COVID-19.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Priority age targets for COVID-19 vaccination in Ethiopia under limited vaccine supply
- Date Crossref
- 31/07/2022
- Éditeur
- openRxiv
- Type
- posted-content
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Udine Department of Mathematics pays non établi dans la noticeUniversité ou école supérieure
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Fondazione Bruno Kessler pays non établi dans la noticeStructure de recherche
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Doctors with Africa Cuamm Addis Abeba, Éthiopie (pays nommé en fin d’affiliation)Organisation à but non lucratif
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Bocconi University Dondena Centre for Research on Social Dynamics and Public Policy pays non établi dans la noticeUniversité ou école supérieure
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Indiana University Bloomington pays non établi dans la noticeUniversité ou école supérieure
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Bruno Kessler Foundation Center for Health Emergencies pays non établi dans la noticeOrganisation à but non lucratif
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Epilab-JRU pays non établi dans la noticeStructure de recherche
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Indiana University School of Public Health Laboratory for Computational Epidemiology and Public Health pays non établi dans la noticeUniversité ou école supérieure
Department of Mathematics — University of Udine, Fondazione Bruno Kessler et Doctors with Africa Cuamm (Addis Abeba, Éthiopie), avec 5 autres affiliations. Pays d’affiliation : Éthiopie.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.