Degradable Glycopolyester-Like Nanoparticles by Radical Ring-Opening Polymerization

Résumé fourni par la source

A small library of degradable polyester-like glycopolymers was successfully prepared by the combination of radical ring-opening copolymerization (rROP) of 2-methylene-1,3-dioxepane (MDO) with vinyl ether (VE) derivatives, and a Pd-catalyzed thioglycoconjugation. The resulting thioglycopolymers were formulated into self-stabilized thioglyconanoparticles which were stable up to 4 months and were enzymatically degraded. Nanoparticles and their degradation products exhibited a good cytocompatibility on two healthy cell lines. Interactions between thioglyconanoparticles and lectins were investigated and highlighted the presence of both specific carbohydrate/lectin interactions and non-specific hydrophobic interactions. Fluorescent thioglyconanoparticles were also prepared either by encapsulation of Nile Red, or by the functionalization of the polymer backbone with Rhodamine B. Such nanoparticles were used to prove the cell internalization of the thioglyconanoparticles by lung adenocarcinoma (A549) cells which underlined the great potential of P(CKA-co-VE) copolymers for biomedical applications

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.