Optimising neonatal antiretroviral therapy using raltegravir: a qualitative analysis of healthcare workers’ and caregivers’ perspectives
Rattachement africain : us, Zimbabwe. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
BACKGROUND: In 2020, Zimbabwe adopted the WHO's recommendation to use raltegravir (RAL) granule-based regimens for treatment of neonates identified with HIV at the time of birth testing. This study explores the acceptability of RAL granules by caregivers and healthcare workers (HCWs). METHODS: Interviews were conducted with 15 caregivers and 12 HCWs from 8 health facilities in Zimbabwe participating in the introductory pilot of RAL granules treatment for newborns. Eligible caregivers included those who had administered RAL to their infant and attended either 8th or 28th day of life appointments. Caregivers of neonates recently initiated on RAL were selected through convenience sampling. Eligible HCWs who provided RAL preparation, administration instructions and support to caregivers of neonates on RAL for at least 3 months were recruited from the same facilities as the caregivers. Interview transcripts were coded and thematically analysed. RESULTS: Caregivers reported that their babies looked healthier after RAL initiation, with improved skin appearance and weight gain. Some caregivers wanted their child to remain on RAL beyond 28 days instead of switching regimens, as recommended by national guidelines. HCWs observed that RAL granules improved health outcomes compared with other regimens. HCWs reported challenges with caregivers understanding dosing instructions, measuring with a syringe, swirling and not shaking the medicine, discarding unused medication and following the changes in the dosing schedule and amount when RAL was initiated a few days after birth. HCWs stated that adequate counselling and repeat demonstrations were crucial to ensure that caregivers clearly understood RAL dosing and administration instructions. HCWs requested more standardised training targeting nurses with guidance on handling missed doses and clarification on mixing RAL granules with water and not breastmilk. CONCLUSION: While feedback from caregivers and HCWs on RAL implementation was positive, barriers were also noted. Adequate training and sufficient instruction and support for caregivers would help to ensure that RAL granules are prepared, dosed and administered correctly.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Optimising neonatal antiretroviral therapy using raltegravir: a qualitative analysis of healthcare workers’ and caregivers’ perspectives
- Date Crossref
- 01/07/2022
- Éditeur
- BMJ
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Elizabeth Glaser Pediatric AIDS Foundation Research Department Harare, Zimbabwe (pays nommé en fin d’affiliation)Organisation à but non lucratif
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Catholic Relief Services pays non établi dans la noticeOrganisation à but non lucratif
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Ministry of Health and Child Welfare Zimbabwe (code pays fourni par la source)Organisme public
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George Washington University Global Health Department pays non établi dans la noticeUniversité ou école supérieure
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Practical Action Zimbabwe (code pays fourni par la source)Organisation à but non lucratif
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Centers for Disease Control and Prevention pays non établi dans la noticeOrganisme public
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National AIDS Council Zimbabwe (code pays fourni par la source)Organisme public
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Health and Social Services Department pays non établi dans la noticeInstitution
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Ministry of Health and Child Care AIDS & TB Department Harare, Zimbabwe (pays nommé en fin d’affiliation)Organisme public
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Division of Global HIV and Tuberculosis Harare, Zimbabwe (pays nommé en fin d’affiliation)Institution
Research Department — Elizabeth Glaser Pediatric AIDS Foundation (Harare, Zimbabwe), Catholic Relief Services et Ministry of Health and Child Welfare (Zimbabwe), avec 7 autres affiliations. Pays d’affiliation : Zimbabwe.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.