[Retracted] Hemodynamic and Geometric Risk Factors for In‐Stent Restenosis in Patients with Intracranial Atherosclerotic Stenosis
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Problem. Investigating the importance of vessel geometry and hemodynamics in intracranial atherosclerotic stenosis (ICAS) might provide a more profound understanding about the underlying mechanisms of in‐stent restenosis (ISR). Methods. Severe ICAS patients managed with percutaneous transluminal angioplasty and stenting (PTAS) were included in the retrospective cohort study and were divided into two groups according to whether ISR occurred at follow‐up (ISR group and no‐ISR group). Computational fluid dynamics models were built based on digital subtraction angiography before and after PTAS to simulate blood flow and quantify hemodynamic parameters. The associations between vessel geometry, hemodynamics, and ISR in ICAS patients were investigated. Results. Among 39 patients, ISR occurred in seven patients (17.95%) after a mean follow‐up period of 6.69 ± 3.24 months. Stenting decreased vessel angulation (51.11° [40.07°–67.27°] vs. 15.97° [0.00°–36.16°], P = 0.000) and vessel tortuosity (0.09 [0.06–0.13] vs. 0.01 [0.00–0.03], P = 0.000). Meanwhile, the translational pressure ratio (PR) dramatically increased (0.07 [0.00–0.31] vs. 0.62 [0.41–0.82], P = 0.000) with the wall shear stress ratio decreased (13.93 [8.37–40.30] vs. 2.90 [1.69–4.48], P = 0.000). In the multivariate analysis, smaller Δ tortuosity (P = 0.038) was independently associated with the occurrence of ISR, and smaller post‐PTAS translesional PR was also a predictive factor of marginal significance (P = 0.059). Conclusion. PTAS decreased vessel angulation, vessel tortuosity, and translesional wall shear stress ratio while it increased translesional pressure ratio (PR) dramatically in ICAS patients. Smaller Δ tortuosity was found to be a risk factor for ISR, and smaller post‐PTAS translesional PR was also a predictive factor of marginal significance, indicating that both geometric and hemodynamic parameters played important roles in the occurrence of ISR after PTAS.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- [Retracted] Hemodynamic and Geometric Risk Factors for In‐Stent Restenosis in Patients with Intracranial Atherosclerotic Stenosis
- Date Crossref
- 01/01/2022
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Capital Medical University Department of Neurosurgery pays non établi dans la noticeUniversité ou école supérieure
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Beijing Tian Tan Hospital pays non établi dans la noticeÉtablissement de santé
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National Clinical Research Center for Digestive Diseases pays non établi dans la noticeÉtablissement de santé
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Chinese Institute for Brain Research pays non établi dans la noticeOrganisme public
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Beijing Institute for Brain Disorders Center of Stroke pays non établi dans la noticeStructure de recherche
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Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease pays non établi dans la noticeStructure de recherche
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China National Clinical Research Center for Neurological Diseases pays non établi dans la noticeStructure de recherche
Department of Neurosurgery — Capital Medical University, Beijing Tian Tan Hospital et National Clinical Research Center for Digestive Diseases, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.