Temporal Trends in the Prevalence, Treatment and Outcomes of Patients with Acute Coronary Syndrome at High Bleeding Risk
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Le résumé fourni par la source
(1) Background: High bleeding risk is associated with adverse outcomes in ACS patients. We aimed to evaluate temporal trends in treatment and outcomes of ACS patients according to bleeding risk. (2) Methods: Included were ACS patients enrolled in ACSIS surveys. Patients were divided into three groups according to enrolment period: early (2002−2004), mid (2006−2010) and recent (2012−2018). Each group was further stratified into three subgroups according to CRUSADE bleeding risk score. The primary endpoints were 30-day MACE and 1-year all-cause mortality. (3) Results: Included were 13,058 ACS patients. High bleeding risk patients were less frequently treated with guideline-based medications and coronary revascularization. They also had higher rates of 30-day MACE and 1-year all-cause mortality regardless of the enrollment period. Among patients enrolled in early period, 30-day MACE rates were 10.8%, 17.5% and 24.3% (p < 0.001) and 1-year all-cause mortality rates were 2%, 7.7% and 23.6% (p < 0.001) in the low, moderate and high bleeding risk groups, respectively. Among patients enrolled in mid period, 30-day MACE rates were 7.7%, 13.4% and 23.5% (p < 0.001) and 1-year all-cause mortality rates were 1.5%, 7.2% and 22.1% (p < 0.001) in low, moderate and high bleeding risk groups, respectively. For patients enrolled in recent period, 30-day MACE rates were 5.7%, 8.6% and 16.2%, (p < 0.001) and 1-year all-cause mortality rates were 2.1%, 6% and 22.4%, (p < 0.001) in low, moderate and high bleeding risk groups, respectively. These differences remained significant following a multivariate analysis. (4) Conclusions: The percentage of patients at high bleeding risk has decreased over the last years. Despite recent improvements in the treatment of ACS patients, high bleeding risk remains a strong predictor of adverse outcomes.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Temporal Trends in the Prevalence, Treatment and Outcomes of Patients with Acute Coronary Syndrome at High Bleeding Risk
- Date Crossref
- 22/07/2022
- Éditeur
- MDPI AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Tel Aviv University pays non établi dans la noticeUniversité ou école supérieure
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Meir Medical Center Cardiology Department pays non établi dans la noticeÉtablissement de santé
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Sheba Medical Center Department of Cardiology pays non établi dans la noticeÉtablissement de santé
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Shaare Zedek Medical Center pays non établi dans la noticeÉtablissement de santé
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Bar-Ilan University pays non établi dans la noticeUniversité ou école supérieure
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Western Galilee Hospital pays non établi dans la noticeÉtablissement de santé
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Sackler Faculty of Medicine pays non établi dans la noticeUniversité ou école supérieure
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The Hebrew University Shaare Zedek Medical Center pays non établi dans la noticeUniversité ou école supérieure
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Azrieli Faculty of Medicine in the Galilee pays non établi dans la noticeUniversité ou école supérieure
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Galilee Medical Center Department of Cardiology pays non établi dans la noticeÉtablissement de santé
Tel Aviv University, Cardiology Department — Meir Medical Center et Department of Cardiology — Sheba Medical Center, avec 7 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.