WF-OCTA for detecting diabetic retinopathy and evaluating the effect of photocoagulation on posterior vitreous detachment

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Abstract Purpose: To assess the clinical usefulness of widefield swept source optical coherence tomography angiography (WF SS-OCTA) for detecting microvasculature lesions in diabetic retinopathy (DR) by comparing with ultra-widefield (UWF) fluorescein angiography (FA). And investigate the effect of panretinal photocoagulation (PRP) on posterior vitreous detachment (PVD) status.Methods: DR patients underwent WF SS-OCTA with 12×12mm scan pattern of five visual fixations at baseline and at least 3-month visit after PRP treatment. Patients with no contraindications were imaged with UWF FA within a week. Images were evaluated in two methods for the areas of visible field of view (FOV), non-perfused area (NPA), presence of neovascularization of disc (NVD), neovascularization elsewhere (NVE) and PVD status.Results: 44 eyes of 28 patients with DR initially treated with PRP were enrolled. The FOV of UWFFA were significantly wider than WF-OCTA. There was a good consistency for quantitative measurement of NPAs between two methods. NPAs more than 5DA outside the panoramic OCTA imaging area were detected in 1 eye with NPDR (8.3%) and 10 eyes with PDR (47.8%). WF-OCTA had high detection for NVDs and NVEs with a low rate of false positives. After PRP treatment, no eyes showed progression in PVD stages around the macula, optical disc and NVEs at short follow-up.Conclusion: WF SS-OCTA is clinically useful for evaluating NPAs and NVs in DR. PRP treatment cannot induce PVD development in a short time.

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