PLEIOTROPIC EFFECT OF MUTATION IN THE GENES INVOLVED IN THE BIOSYNTHESIS OF LIPOPOLYSACCHARIDES OF ERWINIA AMYLOVORA PHYTOPATHOGENIC BACTERIA

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In this study, we constructed Erwinia amylovora deletion mutant by waaC, waaD, waaF, waaL, wabK and wabM genes, coding enzymes involved in the synthesis of lipopolysaccharides of the bacteria outer membrane, and investigated the phenotypic manifestation of the resulting mutation. It was demonstrated that the resulting mutant has an increased ability to autoaggregation and biofilms formation, but is characterized by the reduced mobility and levan exopolysaccharide production. In addition, the deletion of genes of lipopolysaccharides biosynthesis led to the loss of the mutant strain virulence. The data obtained indicate the most important role the lipopolysaccharide layer plays in the virulence of E. amylovora bacteria.

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