Annexin-A1 deficiency attenuates stress-induced tumor growth via fatty acid metabolism in mice: an Integrated multiple omics analysis on the stress- microbiome-metabolite-epigenetic-oncology (SMMEO) axis
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Le résumé fourni par la source
Background: High emotional or psychophysical stress levels have been correlated with an increased risk and progression of various diseases.How stress impacts the gut microbiota to influence metabolism and subsequent cancer progression is unclear.Methods: Feces and serum samples from BALB/c ANXA1 +/+ and ANXA1 -/-mice with or without chronic restraint stress were used for 16S rRNA gene sequencing and GC-MS metabolomics analysis to investigate the effect of stress on microbiome and metabolomics during stress and breast tumorigenesis.Breast tumors samples from stressed and non-stressed mice were used to perform Whole-Genome Bisulfite Sequencing (WGBS) and RNAseq analysis to construct the potential network from candidate hub genes.Finally, machine learning and integrated analysis were used to map the axis from chronic restraint stress to breast cancer development.Results: We report that chronic stress promotes breast tumor growth via a stress-microbiomemetabolite-epigenetic-oncology (SMMEO) axis.Chronic restraint stress in mice alters the microbiome composition and fatty acids metabolism and induces an epigenetic signature in tumors xenografted after stress.Subsequent machine learning and systemic modeling analyses identified a significant correlation among microbiome composition, metabolites, and differentially methylated regions in stressed tumors.Moreover, silencing Annexin-A1 inhibits the changes in the gut microbiome and fatty acid metabolism after stress as well as basal and stress-induced tumor growth.Conclusions: These data support a physiological axis linking the microbiome and metabolites to cancer epigenetics and inflammation.The identification of this axis could propel the next phase of experimental discovery in further understanding the underlying molecular mechanism of tumorigenesis caused by physiological stress.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé, mais le titre doit être comparé manuellement.
- Titre Crossref
- Annexin-A1 deficiency attenuates stress-induced tumor growth <i>via</i> fatty acid metabolism in mice: an Integrated multiple omics analysis on the stress- microbiome-metabolite-epigenetic-oncology (SMMEO) axis
- Date Crossref
- 01/01/2022
- Éditeur
- Ivyspring International Publisher
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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National University of Singapore pays non établi dans la noticeUniversité ou école supérieure
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Duke-NUS Medical School pays non établi dans la noticeUniversité ou école supérieure
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Life Sciences Institute NUS Immunology Program pays non établi dans la noticeStructure de recherche
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National University Health System pays non établi dans la noticeUniversité ou école supérieure
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NUS Environmental Research Institute pays non établi dans la noticeStructure de recherche
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Agency for Science Singapore Immunology Network (SIgN) pays non établi dans la noticeOrganisme public
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Singapore Immunology Network pays non établi dans la noticeStructure de recherche
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Yong Loo Lin School of Medicine Department of Physiology pays non établi dans la noticeUniversité ou école supérieure
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Saw Swee Hock School of Public Health pays non établi dans la noticeUniversité ou école supérieure
National University of Singapore, Duke-NUS Medical School et NUS Immunology Program — Life Sciences Institute, avec 6 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.