Increased MET Copy Number and its Differing Prognostic Values in Schistosomal and Non-Schistosomal Colorectal Cancers

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Abstract Objective: To compare the prognostic role regarding gene copy number alteration of MET in schistosomal colorectal cancer (SCRC) and non-schistosomal colorectal cancer (NSCRC).Methods: This retrospective study included 131 SCRC and 207 NSCRC patients, MET status was evaluated by fluorescent in situ hybridization (FISH) and immunohistochemistry (IHC) in tissue microarray sections.Results: No significant differences were found in terms of clinical characteristics for SCRC patients and NSCRC patients except for age, where significantly more patients over 60 years old presented SCRC than NSCRC (P < 0.001). 10.0% of cases were MET FISH-positive (mean ≥ 3 copies/cell). MET protein expression was positive in 60.3% of cases, but was not associated with MET FISH-positive (P = 0.574). All patients were followed, and the median time was 51.3 months (range, 1.0 – 134.4 months). The prognostic significance of MET FISH-positive was different between SCRC and NSCRC. In SCRC, patients that were MET FISH-positive had significantly shorter survival compared to those that were MET FISH-negative (P = 0.014). In NSCRC, the overall survival shows a slight trend toward favorable prognosis in association with MET FISH-positive for stage I-II patients (P = 0.138), yet MET FISH-positive were significantly correlated to adverse survival for stage III-IV patients (P = 0.015). Conclusions: Increased MET copy number acts as a negative prognostic factor for SCRC, which has bidirectional prognostic significance in NSCRC.

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