Immunohematology and compatibility testing

Le résumé fourni par la source

Immunohematology is the study of the immune response to blood group antigens following stimulation with foreign blood cells through transfusion or pregnancy and the resulting impact on donor-recipient compatibility. Immune responses are divided into two categories: humoral immunity and cell-mediated events. The antigen receptors of both T and B cells consist of two polypeptide chains synthesized under the direction of two different chromosomal loci. Blood group antibodies bind to antigens on the surface of red cells, platelets, or neutrophils. Pretransfusion compatibility testing involves donor unit testing, patient sample collection and testing, and labeling and clerical checks between the donor unit and intended recipient. Confirmation of the ABO/Rhesus of a red cell donor unit is performed on a segment from the unit after the unit has been labeled and before transfusion by the transfusion facility. Automated systems for pretransfusion testing are particularly suited for large hospital-based transfusion services.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.