Accès ouvert déclaré
2022
article
Ventilatory settings in the initial 72 h and their association with outcome in out-of-hospital cardiac arrest patients: a preplanned secondary analysis of the targeted hypothermia versus targeted normothermia after out-of-hospital cardiac arrest (TTM2) trial
Chiara Robba, Rafael Badenes, Denise Battaglini, Lorenzo Ball, Iole Brunetti, Janus Christian Jakobsen, Gisela Lilja, Hans Friberg, Pedro David Wendel‐Garcia, Paul J. Young, Michelle S. Chew, Johan Undén, Matthew Thomas, Michael Joannidis, Alistair Nichol, Andreas Lundin, Jacob Hollenberg, Naomi Hammond, Manoj Saxena, Martin Annborn, Miroslav Solař, Fabio Silvio Taccone, Josef Dankiewicz, Niklas Nielsen, Paolo Pelosi, Jan Bělohlávek, Clifton W. Callaway, Tobias Cronberg, David Erlinge, Jan Hovdenes, Hans Kirkegaard, Helena Levin, Matt Morgan, Per Nordberg, Christian Rylander, Christian Storm, Matt P. Wise, Kathy Rowan, David A Harrison, Paul Mouncey, Manu Shankar‐Hari, Duncan Young, Theis Lange, Karolina Palmér, Ulla-Britt Karlsson, Simon Heissler, Frances Bass, John Myburgh, Colman Taylor, Adele Bellino, Marwa Abel-all, Ben Finfer, Carolyn Koch, Yang Li, Anne O’Connor, Tina Schneider, Anna Tippett, Bridget Ady, Tessa Broadley, Amanda Brown, Liz Melgaard, Mimi Morgan, Vanessa Singh, Rebecca Symons, Kathrin Becker, Nathalie Van Sante, Vendula Saleova, Silvie Zerzanova, Samia Sefir-Kribel, Ute Lübeck, Mario Negri, Martina Carrara, Kathryn Fernando, Diane Mackle, Leanlove Navarra, Judith Riley, Elin Westerheim, Marianne Flatebø, Ameldina Ceric, Zana Haxhija, Lovisa Terling, Lena Bossmar, Liz Jergle, Helén Holm Månsson, Samia Abed Maillard, Andreja Vujičić Žagar, Christina Jodlauk, Helen Hill, Jennifer Scrivens, Kate Ainscough, Ciara Fahey, Rinaldo Bellomo, Leah Peck, Helen Young, Winston Cheung, Rosalba Cross, Michael Hayes, Nitin Jain, Mark Kol, Asim A. Shah, Atul Wagh, F. Eduardo Martinez, Gail Brinkerhoff, Dustin Bush, Antony Stewart, Anders Åneman, Lien Lombardo, Peter McCanny, James Penketh, Ian Seppelt, Rebecca Gresham, Julie Lowrey, Kristy Masters, Christina Whitehead, James Walsham, Meg Harward, Josephine Mackay, Jason Meyer, Emma Saylor, Ellen Venz, Krista Wetzig, Wade Stedman, Angela Ashelford, Sharon Mar, Miyuki Tokumitsu, Elizabeth Yarad, Hergen Buscher, Claire Reynolds, Andrew Udy, Aidan Burrell, Jasmin Collins, Dashiell Gantner, Victoria Emma-Leah Martin, Phoebe Mccracken, Vinodh Nanjayya, Alexander Sacha Richardson, Meredith Young, Angaj Ghosh, Simone Said, Ronny Beer, Frank Hartig, Raimund Helbok, Sebastian Klein, Andreas Peer, Jacques Créteur, D. Durand, Matthias Dupont, Sigrid Christiaens, Carola Claes, Sebastiaan Deckx, Bert Ferdinande, Sanne Lenaerts, Wilifred Mullens, Sarah Stroobants, Evi Theunissen, David Verhaert, Ondřej Šmíd, Marek Flaksa, David Kemlink, Jan Malík, Michal Otáhal, Jan Rulíšek, Michal Šíranec, Zdeněk Stach, Anna Valeriánová, Petra Zavadilova, Róber Bánszky, Jana Červená, R Pařízková, Libor Šimůnek, Filip Varhaník, Jiří Karásek, Matěj Strýček, Anders Morten Grejs, Steffen Christensen, Peter Juhl‐Olsen, Ida Katrine Thomsen, Lisa Gregersen Østergaard, Albert Cao, Pierre Dupland, Ariane Gavaud, Paul Jaubert, Mathieu Jozwiak, Nathalie Marin, Guillaume Savary, Nicolas Deye, Bruno Mégarbane, Pierre Mora, Laetitia Sütterlin, Stéphane Legriel, Hugo Bellut, Alexis Ferré, Guillaume Lacave, Marine Paul Jean-Baptiste Lascarrou, Emmanuel Canet, Charlotte Garret, Arnaud Felix Miaihle, Jean Reignier, Philippe Vignon, Thomas Daix, Arnaud Desachy, Bruno Evrard, Bruno François, Anne-Laure Fedou, Marine Goudelin, Gabriele Kress, Christoph Leithner, Jens Nee, Kaspar Josche Streitberger, Giulia Bonatti, Iacopo Firpo, Paolo Frisoni, Arianna Iachi, Simona Maiani, Maura Mandelli, Fabio Tarantino, Alberto Barbieri, Elisabetta Bertellini, Enrico Giuliani, Gabriele Melegari, Erik Roman‐Pognuz, Giorgio Berlot, Umberto Lucangelo, Elisabetta Macchini, Vibeke Aune, Tomas Drægni, Simon Jacobsen, Søren Pieschke, Åse Rasmussen, Gro Ringstad Akselsen, Halvor Langeland, Daniel Bergum, Therese M. Erbe, Pål Klepstad, Helle M Næss, Roy Bjørkholt Olsen, Lena Eriksen Skjelnes, Marius Holen, Joakim Iver Post, Rune Fanebust, Linda Hårteig Sørensen, Ken Åge Kårstad, Carsten Fredrik Wickman, Colin Barnes, Ben Barry, Niña Beehre, Dick Dinsdale, Sam Edney, Anna Hunt, Harriet Judd, Charlotte Latimer-Bell, Cassie Lawrence, James Moore, Shaanti Olatunji, Alex Psirides, Chelsea Robinson, Kate Tietjens, Jason Wright, David Knight, Brandon Birker, David Bowie, Tara Burke, David Closey, Rosalind Crombie, Neil Davidson, Seton Henderson, Louise Hitchings, James McKay, Jan Mehrtens, Emmeline Minto, Stacey Morgan, Anna Morris, Jay Ritzemar-Carter, Jessica Roberts, Geoff Shaw, Katherine Townend, Kymbalee Vander Heyden, Marita Ahlqvist, Roman Desta Lindgren, Ingrid Eiving, Patrik Martner, Elisabeth Myhrman, Birgitta Ryding, Joachim Düring, Mattias Bergström, Mattias Bohm, Ingrid Didriksson, Petrea Frid, Katarina Heimburg, Marina Larsson, Oscar H. M. Lundberg, Stefan Olsson Hau, Simon Schmidbauer, Ola Borgquist, Anne Adolfsson, Anna Bjärnroos, Erik Nordström, Irina Dragancea, Thomas Kander, Anna Lybeck, Gustav Mattiasson, Olof Persson, Malin Rundgren, Susann Schrey, Erik Westhall, Sara Andertun, Florian Ebner, Nerida Gustavsson, Lisa Hassel, Jesper Johnsson, Marie Nelderup, Heléne Petersson, Jörgen Petersson, Frideriki Stafilidou, Frida Antonsson, Git Bergman, Jörgen Gamroth, Maria Meirik, Katarina Rudolfsson, Helena Sandberg, Martin Thorsson, Kristin Savolainen, Maria Hansbo, Malin Helliksson, Björne Nödtveidt, Johan Sanner, Victoria Sem, Camilla Sund Lindquist, Akil Awad, Anna-Sofia Börjesson, Malin Hedberg, Mia Henning, Per Petersen, Emelia Dahlberg, Johan Forshammar, Veronica Svensson, Michael Wanecek, Håkan Eskilsson, Daniel Rodriguez-Santos, Åsa Appelqvist, Henrietta Jidbratt, Elisabeth Johansson, Lars Kiszakiewicz, Åsa Nilsson, Sinnika Olsson, Anders Paulsson, Urszula Stempel, Andreas Thoren, Stefan Persson, Ida Berglund, Eric Bergström, Cathrine Törnqvist, Ingela Östman, Sten Rubertsson, Ing‐Marie Larsson, Elin Söderman, Ewa Wallin, Joanna Wessbergh, Thomas Halliday, Filippa Engvall, Nawfel Ben‐Hamouda, Adriano Bernini, Pierre‐Nicolas Carron, P. Eckert, Eva Favre, John‐Paul Miroz, Paola Morelli, Olivier Müller, Jan Novi, Andrea Rosseti, Madeleine Schnorf, Matthias Hænggi, Anja Levis, Sandra Nansoz, Nicole Söll, Claudia Schrag, Mensur Alicajic, Philipp Baier, Joel Dütschler, Dominique Flügel, Edith Fässler, Ruth Gamio-Veis, Marc Güpfert, Yvonne Hilpertshauser, Stefan Hägele-Link, Gian‐Reto Kleger, Peter Krähenmann, Maria Elisabeth Mair, Nadja Schai, Christoph Strohmaier, Peter Tangl, Dominik Zieglgänsberger, Marco Maggiorini, Gabriele Claus, Gabi Consani-Vogel, Lukas Imbach, Samira Kaiser, Eva-Maria Kleinert, Tiziano Cassina, Pamela Agazzi, Bruno Capelli, Gabrièle Casso, Martino Regazzi, Hervé Schlotterbeck, Gabriele Via, Michele Villa, Jenny Brooks, Eve Cocks, Jade Cole, Jacqueline Curtin, Michelle Davies, Rhys Davies, Stephen Fernandez, Julie Highfield, Lydia Pennant, Sofia Rose, Emma Thomas, Angharad Williams, Peter McGuigan, Stephen Haffey, Aisling O’Neill, Jeremy Bewley, Anna Chillingworth, Julie Cloake, Libby Cole, Hilary Galvin, Zoe Garland, Lisa Grimmer, Bethany Gumbrill, Lucy Howie, Rebekah Johnson, Chloe Searles, Agnieszka Skorko, Katie Sweet, Victoria Taylor, Denise Webster, Thomas Keeble, Gill Adams, Rajesh Aggarwal, Jo-Anne Cartwright, Steven Church, Gerald Clesham, John R. Davies, Kelly Farrell, Reto Gamma, Jane Harding, Rohan Jagathesan, Alamgir Kabir, Paul A. Kelly, Lauren Kittridge, Maria Maccaroni, Gracie Maloney, Marco Mion, Naveen Nain, Raghunath Nalgirkar, Gyanesh Namjoshi, Stacey Pepper, Emily Redman, Nicholas Robinson, Jeremy Sayer, Amanda Solesbury, Kare H. Tang, Sali Urovi, Kunal Waghmare, Noel Watson, Teresa Webber, Peter Isherwood, Conor Bentley, Colin Bergin, Ronald Carrera, Amy Clark, Lauren B. Cooper, Liesl Despy, Natalie Dooley, Karen Ellis, Emma Fellows, Stephanie Goundry, Samantha Harkett, Christopher McGhee, Aoife Neal, Hazel Smith, Catherine Snelson, Elaine Spruce, Tony Whitehouse, Kamal Yakoub, Andrew Walden, Shauna Bartley, Parminder Bhuie, Matthew Frise, Nicola Jacques, Liza Keating, David Pogson, Zoe Daly, Steve Rose, Jonathan Bannard‐Smith, Rachael Quayle, Nigel Chee, Nina Barratt, Katie Bowman, Debbie Branney, Elizabeth Howe, Maria Letts, Sally Pitts, Luke Vamplew, Sara Difiore Sprouse, Ankur Doshi, Jennifer Fugate, Amy M. Headlee, Eelco F. M. Wijdicks
65Citations signalées — pas une note de qualité
34Institutions déclarées
12Pays d’affiliation déclarés
Résumé fourni par la source
The optimal ventilatory settings in patients after cardiac arrest and their association with outcome remain unclear. The aim of this study was to describe the ventilatory settings applied in the first 72 h of mechanical ventilation in patients after out-of-hospital cardiac arrest and their association with 6-month outcomes. Preplanned sub-analysis of the Target Temperature Management-2 trial. Clinical outcomes were mortality and functional status (assessed by the Modified Rankin Scale) 6 months after randomization. A total of 1848 patients were included (mean age 64 [Standard Deviation, SD = 14] years). At 6 months, 950 (51%) patients were alive and 898 (49%) were dead. Median tidal volume ( V T ) was 7 (Interquartile range, IQR = 6.2–8.5) mL per Predicted Body Weight (PBW), positive end expiratory pressure (PEEP) was 7 (IQR = 5–9) cmH 2 0, plateau pressure was 20 cmH 2 0 (IQR = 17–23), driving pressure was 12 cmH 2 0 (IQR = 10–15), mechanical power 16.2 J/min (IQR = 12.1–21.8), ventilatory ratio was 1.27 (IQR = 1.04–1.6), and respiratory rate was 17 breaths/minute (IQR = 14–20). Median partial pressure of oxygen was 87 mmHg (IQR = 75–105), and partial pressure of carbon dioxide was 40.5 mmHg (IQR = 36–45.7). Respiratory rate, driving pressure, and mechanical power were independently associated with 6-month mortality (omnibus p-values for their non-linear trajectories: p < 0.0001, p = 0.026, and p = 0.029, respectively). Respiratory rate and driving pressure were also independently associated with poor neurological outcome (odds ratio, OR = 1.035, 95% confidence interval, CI = 1.003–1.068, p = 0.030, and OR = 1.005, 95% CI = 1.001–1.036, p = 0.048). A composite formula calculated as [(4*driving pressure) + respiratory rate] was independently associated with mortality and poor neurological outcome. Protective ventilation strategies are commonly applied in patients after cardiac arrest. Ventilator settings in the first 72 h after hospital admission, in particular driving pressure and respiratory rate, may influence 6-month outcomes.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Ventilatory settings in the initial 72 h and their association with outcome in out-of-hospital cardiac arrest patients: a preplanned secondary analysis of the targeted hypothermia versus targeted normothermia after out-of-hospital cardiac arrest (TTM2) trial
- Date Crossref
- 02/07/2022
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude et ne compte pas comme une seconde source scientifique indépendante.
Institutions déclarées
Une affiliation ne permet pas de déduire la nationalité d’un auteur.
Sujets associés
Cardiac Arrest and ResuscitationSepsis Diagnosis and TreatmentRespiratory Support and Mechanisms