Detection of Marburg Virus Disease in Guinea

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T h e ne w e ngl a nd jou r na l o f m e dicine n engl j med 386;26 nejm.orgJune 30, 2022 single mutants (i.e., BA.2_L452Q and BA.2_ S704L) had neutralizing-antibody escape that was similar to that of the BA.4/5 and BA.2.12.1 subvariants, with neutralizing-antibody titers that were 14.1% and 26.6% lower, respectively, than those against BA.2 (P>0.05 for both comparisons) (Fig. 1D).Notably, 2 of 30 BA.1-infected but unvaccinated patients (Patients U12 and U13) had high neutralizing-antibody titers against all the variants except BA.4/5, whereas patients who had received a booster dose had broader neutralization against all the variants examined (Fig. S3C and S3D).Overall, these results showed that infection during the BA.1 wave did not appear to offer effective protection against the newly emerged sublineages.In this study, we characterized infectioninduced immunity and vaccine-induced immunity against newly emerged omicron subvariants.Booster vaccination provided sufficient neutralizing-antibody titers against the BA.4/5 and BA.2.12.1 subvariants, albeit to a lower extent than against BA.1 and BA.2.4,5 These findings underscore the importance of booster vaccination for protection against emerging variants.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.