Early as compared to late initiation of twice‐weekly hemodialysis and short‐term survival among end‐stage renal disease patients
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Le résumé fourni par la source
Abstract Introduction The impact of timing of hemodialysis (HD) for end‐stage renal disease (ESRD) patients treated with twice‐weekly HD remains unclear. We aimed to determine the effects of late initiation of HD on short‐term mortality and hospitalization. Methods A multicenter cohort study was conducted in 11 HD centers in Northeastern Thailand (HEmodialysis Network of the NorthEastern Thailand study group). We recruited adult ESRD patients who were treated with twice‐weekly HD for more than 3 months and had data on eGFR at HD initiation. Clinical and laboratory values at the time of recruitment were recorded. Late and early (eGFR at start <5 and >5 ml/min/1.73 m2) initiations were defined. Outcomes were disease‐related death (excluding any accidental deaths) and first hospitalization. Data analysis was performed by multivariable cox‐regression analysis. Findings A total of 407 patients who had data on eGFR at HD initiation (303 in late group and 104 in early group) were included for analysis. There were 56.8% male with a mean age of 55 years. During the 15.1 months of follow‐up, there were 27 (6.6%) disease‐related deaths. The 1‐year survival rate was similar among late and early initiation groups. The incidence density of first hospitalization in the late group was significantly lower than those in the early group (HR adjusted, 0.63; 95% CI, 0.40–0.99, p = 0.047). Among 303 patients who were in the late start group, patients with diabetes had a higher mortality rate (HR, 3.49; 95% CI, 1.40–8.70, p = 0.007) when compared to non‐diabetic patients. Discussion Early initiation of HD at eGFR >5 ml/min/1.73 m2 had no short‐term survival benefit compared to the late group in ESRD patients treated with twice‐weekly HD for at least 3 months in a resource‐limited setting. A survival benefit from an early start of HD was found among diabetic patients.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Early as compared to late initiation of twice‐weekly hemodialysis and short‐term survival among end‐stage renal disease patients
- Date Crossref
- 21/06/2022
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Khon Kaen University Department of Medicine pays non établi dans la noticeUniversité ou école supérieure
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Khon Kaen Hospital Department of Medicine pays non établi dans la noticeÉtablissement de santé
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Mahidol University Department of Medicine pays non établi dans la noticeUniversité ou école supérieure
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Ramathibodi Hospital pays non établi dans la noticeÉtablissement de santé
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Roi et Rajabhat University pays non établi dans la noticeUniversité ou école supérieure
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Roi Et Hospital Department of Medicine pays non établi dans la noticeÉtablissement de santé
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Maharat Nakhon Ratchasima Hospital pays non établi dans la noticeÉtablissement de santé
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Surin Hospital Department of Medicine pays non établi dans la noticeÉtablissement de santé
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Thai Health Promotion Foundation pays non établi dans la noticeOrganisme public
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Udon Thani Hospital Department of Medicine pays non établi dans la noticeÉtablissement de santé
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Hatyai Hospital pays non établi dans la noticeÉtablissement de santé
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Maharaj Nakorn Chiang Mai Hospital pays non établi dans la noticeÉtablissement de santé
Department of Medicine — Khon Kaen University, Department of Medicine — Khon Kaen Hospital et Department of Medicine — Mahidol University, avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.