CD14 and Related Genes in Respiratory Morbidity After Respiratory Syncytial Virus Infection
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Le résumé fourni par la source
To theEditor—Host factors influence respiratory syncytial virus (RSV) susceptibility and course. We and others have reported several genes that are differentially expressed in RSV-infected patients compared to healthy controls [1, 2], as well as genetic variation of the host that might constitute increased susceptibility to RSV infection [3]. We have also investigated the role of host epigenome in respiratory morbidity after RSV infection [4], by interrogating the DNA methylation pattern of children who completely recovered from infection and children who developed sequelae, namely, recurrent wheezing and asthma. The results of this investigation suggest that methylation could also play an important role in long-term sequelae following RSV infection. Besteman et al [5] recently described an autosomal recessive CD14 deficiency provoked by a single-nucleotide deletion in a patient developing recurrent RSV bronchiolitis. Motivated by this finding and in line with our previous results [4], we investigated gene expression of CD14 during the acute phase of infection in the context of sequelae of severe RSV infection. We have analyzed the role of the epigenome in the respiratory morbidity after RSV infection by comparing methylation patterns from children who develop recurrent wheezing (RW-RSV; n = 36), those with subsequent asthma (AS-RSV; n = 9), and children completely recovered from infection (CR-RSV; n = 32) [4]. In addition, we have obtained RNAseq data for a subset of the same patients analyzed for the epigenome (n = 20) and additional ones (n = 5) (RW-RSV, n = 14; AS-RSV, n = 3; CR-RSV, n = 7). Written informed consent was obtained from parents or guardians using approved permission from the Ethical Committee of Clinical Investigation of Galicia (CEIC ref 2010/015).
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé, mais le titre doit être comparé manuellement.
- Titre Crossref
- <i>CD14</i> and Related Genes in Respiratory Morbidity After Respiratory Syncytial Virus Infection
- Date Crossref
- 17/06/2022
- Éditeur
- Oxford University Press (OUP)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Universidade de Santiago de Compostela Instituto de Investigación Sanitaria de Santiago pays non établi dans la noticeUniversité ou école supérieure
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Centro de Investigación Biomédica en Red de Enfermedades Respiratorias pays non établi dans la noticeStructure de recherche
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Instituto de Investigación Sanitaria de Santiago Genetics of Populations in Biomedicine (GenPoB) Research Group pays non établi dans la noticeStructure de recherche
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Complejo Hospitalario Universitario de Santiago pays non établi dans la noticeÉtablissement de santé
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Hospital Clínico Universitario de Santiago de Compostela Department of Pediatrics pays non établi dans la noticeÉtablissement de santé
Instituto de Investigación Sanitaria de Santiago — Universidade de Santiago de Compostela, Centro de Investigación Biomédica en Red de Enfermedades Respiratorias et Genetics of Populations in Biomedicine (GenPoB) Research Group — Instituto de Investigación Sanitaria de Santiago, avec 2 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.