Current and Future Approaches in Management of Chronic Spontaneous Urticaria Using Anti-IgE Antibodies
Rattachement africain : ro. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Chronic spontaneous urticaria (CSU) considerably alters patients' quality of life, often for extended periods, due to pruriginous skin lesions, impaired sleep, unexpected development of angioedema, and failure of conventional treatments in properly controlling signs and symptoms. Recent research focused on the development of new therapeutic agents with higher efficacy. Although the production of specific immunoglobulin E (IgE) antibodies against certain allergens is not a characteristic of the disease, treatment with omalizumab, a monoclonal anti-IgE antibody, proved efficient and safe in patients with moderate to severe chronic spontaneous urticaria uncontrolled by H1-antihistamines. Ligelizumab, a high-affinity monoclonal anti-IgE antibody, may also efficiently relieve symptoms of unresponsive chronic urticaria to standard therapies. This comprehensive review aims to present recently acquired knowledge on managing chronic spontaneous urticaria with new anti-IgE antibodies. We conducted extensive research on the main databases (PubMed, Google Scholar, and Web of Science) with no restrictions on the years covered, using the search terms "anti-IgE antibodies", "omalizumab", "ligelizumab", and "chronic spontaneous urticaria". The inclusion criteria were English written articles, and the exclusion criteria were animal-related studies. ClinicalTrials.gov was also reviewed for recent relevant clinical trials related to CSU treatment. CSU is a challenging disease with a significant effect on patients' quality of life. Current therapies often fail to control signs and symptoms, and additional treatment is needed. New biologic therapies against IgE antibodies and FcεRIα receptors are currently under investigation in advanced clinical trials. We reviewed recently published data on CSU management using these novel treatments. The development of new and improved treatments for CSU will lead to a more personalized therapeutical approach for patients and provide guidance for physicians in better understanding disease mechanisms. However, some agents are still in clinical trials, and more research is needed to establish the safety and efficacy of these treatments.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Current and Future Approaches in Management of Chronic Spontaneous Urticaria Using Anti-IgE Antibodies
- Date Crossref
- 17/06/2022
- Éditeur
- MDPI AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Carol Davila University of Medicine and Pharmacy pays non établi dans la noticeUniversité ou école supérieure
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Clinical Emergency Hospital Bucharest pays non établi dans la noticeÉtablissement de santé
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University of Medicine and Pharmacy of Craiova Dermatology Department pays non établi dans la noticeUniversité ou école supérieure
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“Carol Davila” University of Medicine and Pharmacy Dermatology Department pays non établi dans la noticeUniversité ou école supérieure
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“Elias” University Emergency Hospital Dermatology Department pays non établi dans la noticeUniversité ou école supérieure
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"Carol Davila" University of Medicine and Pharmacy Dermatology Department pays non établi dans la noticeUniversité ou école supérieure
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"Elias" University Emergency Hospital Dermatology Department pays non établi dans la noticeUniversité ou école supérieure
Carol Davila University of Medicine and Pharmacy, Clinical Emergency Hospital Bucharest et Dermatology Department — University of Medicine and Pharmacy of Craiova, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.