Moderate‐ and High‐Intensity Exercise Improves Lipoprotein Profile and Cholesterol Efflux Capacity in Healthy Young Men
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Le résumé fourni par la source
Background Exercise is associated with a reduced risk of cardiovascular disease. Increased high‐density lipoprotein cholesterol (HDL‐C) levels are thought to contribute to these benefits, but much of the research in this area has been limited by lack of well‐controlled subject selection and exercise interventions. We sought to study the effect of moderate and high‐intensity exercise on HDL function, lipid/lipoprotein profile, and other cardiometabolic parameters in a homogeneous population where exercise, daily routine, sleep patterns, and living conditions were carefully controlled. Methods and Results Male Army recruits (n=115, age 22±0.3 years) completed a 12‐week moderate‐intensity exercise program. A subset of 51 subsequently completed a 15‐week high‐intensity exercise program. Fitness increased and body fat decreased after moderate‐ and high‐intensity exercise ( P <0.001). Moderate‐intensity exercise increased HDL‐C and apolipoprotein A‐I levels (6.6%, 11.6% respectively), and decreased low‐density lipoprotein cholesterol and apolipoprotein B levels (7.2%, 4.9% respectively) (all P <0.01). HDL‐C and apolipoprotein A‐I levels further increased by 8.2% ( P <0.001) and 6.3% ( P <0.05) after high‐intensity exercise. Moderate‐intensity exercise increased ABCA‐1 (ATP‐binding cassette transporter A1) mediated cholesterol efflux by 13.5% ( P <0.001), which was sustained after high‐intensity exercise. In a selected subset the ability of HDLs to inhibit ICAM‐1 (intercellular adhesion molecule‐1) expression decreased after the high ( P <0.001) but not the moderate‐intensity exercise program. Conclusions When controlling for exercise patterns, diet, and sleep, moderate‐intensity exercise improved HDL function, lipid/lipoprotein profile, fitness, and body composition. A sequential moderate followed by high‐intensity exercise program showed sustained or incremental benefits in these parameters. Improved HDL function may be part of the mechanism by which exercise reduces cardiovascular disease risk.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Moderate‐ and High‐Intensity Exercise Improves Lipoprotein Profile and Cholesterol Efflux Capacity in Healthy Young Men
- Date Crossref
- 21/06/2022
- Éditeur
- Ovid Technologies (Wolters Kluwer Health)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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The University of Sydney David S. Celermajer https://orcid.org/0000-0001-7640-0439 Heart Research Institute pays non établi dans la noticeUniversité ou école supérieure
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Royal Brisbane and Women's Hospital pays non établi dans la noticeÉtablissement de santé
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The Heart Research Institute pays non établi dans la noticeStructure de recherche
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Anzac Research Institute pays non établi dans la noticeStructure de recherche
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Royal Prince Alfred Hospital pays non établi dans la noticeÉtablissement de santé
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UNSW Sydney pays non établi dans la noticeUniversité ou école supérieure
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Heart Research Institute Sydney New South Wales Australia pays non établi dans la noticeStructure de recherche
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Vivian Kienzle Heart Research Institute pays non établi dans la noticeStructure de recherche
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Leonard Kritharides https://orcid.org/0000-0001-5818-8024 Heart Research Institute pays non établi dans la noticeStructure de recherche
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The University of New South Wales Sydney New South Wales Australia pays non établi dans la noticeUniversité ou école supérieure
David S. Celermajer https://orcid.org/0000-0001-7640-0439 Heart Research Institute — The University of Sydney, Royal Brisbane and Women's Hospital et The Heart Research Institute, avec 7 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.