Accès ouvert déclaré
2022
article
Increased risk of severe COVID-19 in hospitalized patients with SARS-CoV-2 Alpha variant infection: a multicentre matched cohort study
Guillaume Martin‐Blondel, François‐Xavier Lescure, Lambert Assoumou, Jean-Marc Chapplain, Thomas Perpoint, Gaspard Grouteau, Hugues Cordel, Gilles Pialoux, Jérome Pacanowski, Michaël Thy, Adeline Bauvois, Didier Laureillard, Fadia Hamrouni, Michèle Algarté-Génin, Julien Poissy, Dominique Costagliola, Pierre Delobel, Jean Roch Le Henaff, Vincent Mear, Sandra Lagarrigues, Alais Frelat, Thomas De Nadaï, Zara Steinmeyer, Arnaud Del Bello, Stéphanie Ruiz, Benjamine Sarton, Elise Noël‐Savina, Jacques Izopet, Nathan Peiffer-Smadja, Mathilde Garé, Diane Le Pluart, C. Rioux, Laurène Deconinck, Yazdan Yazdanpanah, Pierre Tattevin, Maude Bouscambert‐Duchamp, Hodane Yonis, Paul Chabert, Youssouf Mohamed-Kassim, Nolan Hassold, Ségolène Brichler, Julien Caliez, Thomas Rambaud, Marilucy Lopez‐Sublet, Frédéric Adnet, Christia Palacios, Marwa Bachir, Marine Nadal, Mathieu turpin, Antoine Parrot, Djeneba Fofana, Karine Lacombe, Emmanuelle Gras, Laura Levi, Laure Surgers, Inès Devred, Nadia Valin, Thibault Chiarabini, Jean Luc Meynard, Clara Duran, Elyanne Gault, Jean‐Emmanuel Kahn, Elisabeth Rouveix, Guillaume Géri, Albert Sotto, Paul Loubet, Claire Roger, Marc Lambert, Ady Assaf, Laurence Bocket, Firouzé Bani‐Sadr, Yohan N’Guyen, Juliette Romaru, Maxime Hentzien, Thomas Gabas, Amélie Chabrol, Cecilia Billiou, Philippe Menager, Christophe Billy, J.-J. Laurichesse, Fabrice Ketty N. Simba, Pauline Caraux Paz, Liliane Tinang, Agathe Bounhiol, Catherine Burnat, S. Soriot‐Thomas, Damien Basille, Jean Philippe Lanoix, Yoan Zerbib, Yoann Zerbib, Anne Pouvaret, Fanny Lanternier, H. Mascitti, Aurélien Dinh, Benjamin Davido, Philippe Lesprit, Service de Biologie Clinique Philippe Les, Éric Farfour, Mathilde Neuville, Linda Nait Allaoua, Michèle Lejaille, Nathalie De Castro, Jean‐Michel Molina, Diane Ponscarme, Mariagrazia Tateo, Geoffroy Liégeon, Ines Boussen, Pauline Huriez, André Cabie, Valentine Campana, Isabelle Calmont, Jean-Marie Turmel, Guitteaud Karine, Pierre-François Sandrine, A Marquise, Ornella Cabras, Mélanie Lehoux, Cyrille Chabartier, Vincent Dubée, Diama Ndiaye, Caroline Lefeuvre, Achille Kouatchet, Duc Thanh Nguyen, Camille Tumiotto, Pierre Sioniac, Alexandre Boyer, Jean-François Faucher, E. Desvaux, Sylvie Ranger‐Rogez, Paul Le Turnier, F. Raffi, Emmanuel Canet, Antoine Roquilly, Louise Castain, Solène Sécher, V. Mondain, Lionel Piroth, Christelle Auvray, P. Chavanet, Marielle Buisson, Sophie Mahy, François-Xavier Catherine, Clémentine Estève, Michel Duong, Carole Charles, Sandrine Gohier, Céline Schaffer, Olivier Robineau, Perrine Bortolotti, M. Pradier, François Goehringer, Alice Corbel, Jeanne Kotzyba, Kévin Alexandre, G. Béduneau, Élodie Alessandri-Gradt, M. Martinot, Simon Gravier, Ciprian Ion, Victoire de Lastours, Roza Rahli, Valérie Garrait, Laurent Richier, Mounira Smati-Lafarge, Guillemette Frémont, Pierre Louis Nivose, M. André, M. Gérin, A. Hamdi, N. Sayre, Stephanie Cossec, Sophie Alviset, Pierre Alain Billy, Marie Gousseff, E. Forestier, Anne-Laure Destrem, O. Rogeaux, Alexie Bosch, Sabrina Bryant, Gaëlle Bourgeois, Ophélie Dos Santos Schaller, Marie-Christine Carret, N. Ettahar, Haciba Moudjahed, Nathalie Léone, M. Djennaoui, Nicolas Lefèbvre, Axel Ursenbach, François Danion, Yvon Ruch, Morgane Solis, Hamid Merdji, Loïc Kassègne, Fanny Pommeret, Emeline Colomba Blameble, Merad Manssouria, Annabelle Stoclin, Frank Griscelli, Sophie Deriaz, E. Oziol, Laurent Favier, Julien Obiols, Pascal Gicquel, C. Rapp, Laurence Louvet, Paul Ihout, Jean‐benoît Zabbe, Laurent Bellec, Tomasz Chroboczek, Sandrine Mégessier, Marie Lacoste, Benjamin Viala, T. Challan-Belval, C. Wackenheim, P. Letertre-Gibert, Olivier Grossi
2Citations signalées — pas une note de qualité
34Institutions déclarées
2Pays d’affiliation déclarés
Résumé fourni par la source
BACKGROUND: The impact of the variant of concern (VOC) Alpha on the severity of COVID-19 has been debated. We report our analysis in France. METHODS: We conducted an exposed/unexposed cohort study with retrospective data collection, comparing patients infected by VOC Alpha to contemporaneous patients infected by historical lineages. Participants were matched on age (± 2.5 years), sex and region of hospitalization. The primary endpoint was the proportion of hospitalized participants with severe COVID-19, defined as a WHO-scale > 5 or by the need of a non-rebreather mask, occurring up to day 29 after admission. We used a logistic regression model stratified on each matched pair and accounting for factors known to be associated with the severity of the disease. RESULTS: We included 650 pairs of patients hospitalized between Jan 1, 2021, and Feb 28, 2021, in 47 hospitals. Median age was 70 years and 61.3% of participants were male. The proportion of participants with comorbidities was high in both groups (85.0% vs 90%, p = 0.004). Infection by VOC Alpha was associated with a higher odds of severe COVID-19 (41.7% vs 38.5%-aOR = 1.33 95% CI [1.03-1.72]). CONCLUSION: Infection by the VOC Alpha was associated with a higher odds of severe COVID-19.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Increased risk of severe COVID-19 in hospitalized patients with SARS-CoV-2 Alpha variant infection: a multicentre matched cohort study
- Date Crossref
- 13/06/2022
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude et ne compte pas comme une seconde source scientifique indépendante.
Institutions déclarées
Une affiliation ne permet pas de déduire la nationalité d’un auteur.
Sujets associés
COVID-19 Clinical Research StudiesLong-Term Effects of COVID-19SARS-CoV-2 and COVID-19 Research