Phosphorylation of 10-bromoanthracen-9-yl-cyclopenta[d]isoxazol-6-ols: chemistry suitable for antivirals

Résumé fourni par la source

Regioisomeric nor-nucleoside analogues, brominated at the anthracene ring, have been prepared and phosphorylated according to different protocols affording a variety of phosphate and phosphonate derivatives.Chiral phosphorus derivatives were also obtained as inseparable mixtures of diastereisomers.The synthetic methods are described and found to be reliable and robust, affording nor-nucleosides and nornucleotides, available in large amounts for in vitro antiviral evaluation.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.