Real-world experience managing unresectable or metastatic small cell carcinoma of the prostate
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Le résumé fourni par la source
INTRODUCTION: Unresectable and metastatic small cell carcinoma of the prostate (SCPC) is a rare and aggressive disease that is under-represented in clinical trials. We carried out a retrospective chart review of metastatic or unresectable SCPC patients at British Columbia (BC) Cancer centers, studying diagnosis and treatment patterns. METHODS: Drug-dispensing records from the six BC Cancer centers were obtained from 2002-2017. For each patient, information was collected on baseline information prior to therapy and for each line of treatment. Treatments at each line were compared regarding time to progression and overall survival by Kaplan-Meier curves. RESULTS: Forty-one patients received treatment; 65.6% had metastatic disease and 61% had pure small cell carcinoma. Median time from treatment to death was 10 months (95% confidence interval [CI] 6-16). Patients with initially prostate-confined disease had a better median overall survival (mOS) of 21 months (95% CI 13-34) compared to those with initially locally advanced (mOS 19 months, 95% CI 5-37) and metastatic disease (mOS 8 months, 95% CI 6-10) (log-rank p=0.0364). All patients received either cisplatin- or carboplatin-based combination chemotherapy as the first-line treatment and 36.7% received second-line therapy. Time to second-line therapy was eight months for those who presented with metastatic SCPC, compared to 13 months for those with initial non-metastatic SCPC. CONCLUSIONS: This single-province, multi-institution cohort reports data on unresectable and metastatic SCPC and highlights the poor prognosis of this rare disease entity.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Real-world experience managing unresectable or metastatic small cell carcinoma of the prostate
- Date Crossref
- 09/06/2022
- Éditeur
- Canadian Urological Association Journal
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Abbotsford Veterinary Clinic pays non établi dans la noticeÉtablissement de santé
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University of British Columbia pays non établi dans la noticeUniversité ou école supérieure
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Island Health pays non établi dans la noticeÉtablissement de santé
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BC Cancer Agency pays non établi dans la noticeÉtablissement de santé
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Department of Medical Oncology pays non établi dans la noticeInstitution
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Research and Capacity Building Department pays non établi dans la noticeInstitution
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Data and Analytics pays non établi dans la noticeInstitution
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Department of Radiation Oncology pays non établi dans la noticeInstitution
Abbotsford Veterinary Clinic, University of British Columbia et Island Health, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.