Comparison of point‐shear wave elastography (ElastPQ) and transient elastography (FibroScan) for liver fibrosis staging in patients with non‐alcoholic fatty liver disease
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Le résumé fourni par la source
BACKGROUND AND AIMS: ElastPQ is a point shear wave elastography technique used to non-invasively assess liver fibrosis. We compared liver stiffness measurements (LSM) by ElastPQ and fibroscan transient elastography (F-TE) in a cohort of patients with non-alcoholic fatty liver disease (NAFLD). We further evaluated the performance of ElastPQ in a subgroup of patients with available liver histology. MATERIALS AND METHODS: We included patients with NAFLD who presented in a dedicated multidisciplinary clinic. Anthropometric parameters, blood tests and elastography measurements were obtained using F-TE and ElastPQ as part of routine clinical care. RESULTS: , 56.6% males, 41% diabetes, 53.7% hypertension, 68% dyslipidaemia. ElastPQ showed an excellent correlation with F-TE (Spearman's r = 0.80, p < .001), which was better for mild/moderate stages of fibrosis. Independent predictors of a >2 kPa discrepancy between the two techniques were a larger waist circumference and F-TE ≥10 kPa. In the subgroup of 159 patients with available histology, ElastPQ showed similar diagnostic accuracy with F-TE in staging liver fibrosis (ElastPQ area under the curves 0.84, 0.83, 0.86 and 0.95, for F ≥ 1, F ≥ 2, F ≥ 3 and F = 4 respectively). Optimal cut-off values of ElastPQ for individual fibrosis stages were lower than those of F-TE. CONCLUSIONS: ElastPQ shows an excellent correlation with F-TE in patients with NAFLD, which was better for lower LSM. The optimal cut-off values of ElastPQ are lower than those of F-TE for individual stages of fibrosis. ElastPQ has similar diagnostic accuracy to F-TE for all stages of fibrosis.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Comparison of point‐shear wave elastography (ElastPQ) and transient elastography (FibroScan) for liver fibrosis staging in patients with non‐alcoholic fatty liver disease
- Date Crossref
- 15/06/2022
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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The Royal Free Hospital pays non établi dans la noticeÉtablissement de santé
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University College London pays non établi dans la noticeUniversité ou école supérieure
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University of Modena and Reggio Emilia Division of Medicine and CeMEF pays non établi dans la noticeUniversité ou école supérieure
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University of Messina Division of Clinical and Molecular Hepatology pays non établi dans la noticeUniversité ou école supérieure
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University of Verona Department of Medicine Azienda Ospedaliera Universitaria Integrata pays non établi dans la noticeUniversité ou école supérieure
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Azienda Ospedaliera Universitaria Integrata Verona pays non établi dans la noticeÉtablissement de santé
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UCL Institute for Liver and Digestive Health Royal Free Hospital and UCL London UK pays non établi dans la noticeStructure de recherche
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Department of Internal Medicine University Hospital and School of Medicine of Messina Messina Italy Department of Internal Medicine pays non établi dans la noticeUniversité ou école supérieure
The Royal Free Hospital, University College London et Division of Medicine and CeMEF — University of Modena and Reggio Emilia, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.