Limitation of ctrA as a Target for Neisseria meningitidis Identification and Potential Alternative Targets

Résumé fourni par la source

The genetic diversity of Neisseria meningitidis makes reliable laboratory detection of this important pathogen difficult. Although matrix-assisted laser desorption ionization–time of flight mass spectrometry (MALDI-TOF MS) has been widely adopted for identification of bacteria from clinical samples (1–3), it does not yet reliably distinguish between N. meningitidis and several nonpathogenic Neisseria species, such as Neisseria cinerea and Neisseria polysaccharea (1, 4–10). This is most likely due to the high degree of genetic relatedness between N. meningitidis and the commensal Neisseria species. Therefore, the use of complementary laboratory techniques, including PCR, 16S rRNA sequencing, and traditional biochemical tests, is typically recommended for identification of N. meningitidis (3, 5, 7, 8, 11–13).

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.