Accès ouvert déclaré
2022
article
Clinical and organizational factors associated with mortality during the peak of first COVID-19 wave: the global UNITE-COVID study
Massimiliano Greco, Thomas De Corte, Ari Ercole, Massimo Antonelli, Élie Azoulay, Giuseppe Citerio, Andrew Conway Morris, Gennaro De Pascale, František Duška, Paul Elbers, Sharon Einav, Lui G. Forni, Laurą Galarza, Armand R. J. Girbes, Giacomo Grasselli, V. G. Gusarov, Alasdair Jubb, Jozef Kesecioğlu, Andrea Lavinio, M.C. Martín Delgado, Johannes Mellinghoff, Sheila Nainan Myatra, Marlies Ostermann, Mariangela Pellegrini, Pedro Póvoa, Stefan J. Schaller, Jean–Louis Teboul, Adrian Wong, Jan J. De Waele, Maurizio Cecconi, Marco Bezzi, Alicia Gira, Philipp Eller, Tarikul Hamid, Injamam Ull Haque, Wim De Buyser, Antonella Cudia, Daniel De Backer, Pierre Foulon, Vincent Collin, Jolien Van Hecke, Elisabeth De Waele, Claire Van Malderen, Jean-Baptiste Mesland, Patrick Biston, Michaël Piagnerelli, Lionel Haentjens, Nicolas De Schryver, Jan Van Leemput, Philippe Vanhove, Pierre Bulpa, Viktoria Ilieva, David Katz, Alexandra Binnie, Anna Geagea, Fernando Tirapegui, Gustavo Lago, Jerónimo Graf, Rodrigo Perez-Araos, Patricio Vargas, Felipe Martínez, Eduardo Labarca, Daniel Franco, Daniela Parra-Tanoux, Luis Felipe Reyes, David Yepes, Filip Periš, Sanda Stojanović Stipić, Cynthia Vanessa Campozano Burgos, Paulo Roberto Navas Boada, Jose Luis Barberan Brun, Juan Pablo Paredes Ballesteros, G. Abdel-Nasser, Ahmed Hammouda, Omar Elmandouh, Ahmed Y. Azzam, Aliae Mohamed Hussein, Islam Galal, Ahmed K. Awad, Mohammed A. Azab, Maged Abdalla, Hebatallah Hany Assal, Mostafa Alfishawy, Sherief Ghozy, Samar Tharwat, Abdullah Eldaly, Anneli Ellervee, Veronika Reinhard, Anne Chrisment, Chrystelle Poyat, Julio Badié, Fernando Berdaguer Ferrari, Björn Weiß, Clara Schellenberg, Julius J. Grunow, Marco Lorenz, Peter Spieth, Marc Bota, Falk Fichtner, Kristina Fuest, Tobias Lahmer, Johannes Herrmann, Patrick Meybohm, Νικόλαος Μάρκου, Georgia Vasileiadou, Evangelia Chrysanthopoulou, Panagiotis Papamichalis, Ioanna Soultati, Sameer Jog, Kushal Kalvit, Ivan Krupa, Aisa Tharwat, Alistair Nichol, Aine McCarthy, Ata Mahmoodpoor, Tommaso Tonetti, Paolo Isoni, Savino Spadaro, Carlo Alberto Volta, Lucia Mirabella, Alberto Noto, Gaetano Florio, Amedeo Guzzardella, Chiara Paleari, Federica Baccanelli, Marzia Savi, San Luca, Barbara Vaccarini, Giorgia Montrucchio, Gabriele Sales, Katia Donadello, Leonardo Gottin, Marta Nizzero, Enrico Polati, Silvia De Rosa, Demet Sulemanji, Abdurraouf Abusalama, Muhammed Elhadi, Montelongo De FelipeJesus, Daniel González, Víctor Hugo Madrigal Robles, Nancy Canedo, Alejandro Esquivel Chavez, Tarek Dendane, Bart Grady, Ben de Jong, Eveline van der Heiden, Patrick Thoral, Bas van den Bogaard, Peter E. Spronk, Sefanja Achterberg, Melanie Groeneveld, Ralph K. L. So, Calvin de Wijs, Harm J. Scholten, Albertus Beishuizen, Alexander D. Cornet, Auke C. Reidinga, Hetty Kranen, Roos Mensink, Spaarne Gasthuis, Sylvia den Boer, Marcel de Groot, Oliver Beck, Carina Bethlehem, Bas C. T. van Bussel, Tim Frenzel, Celestine de Jong, Rob Wilting, Jannet Mehagnoul-Schipper, Datonye Alasia, Ashok Kumar, Ahad Qayyum, Muhammad Suleman Rana, Mustafa Abu Jayyab, Rosario Quispe Sierra, Aaron Mark Hernandez, José de Arimatéia Costa de Almeida, Lúcia Taborda, Mónica Anselmo, Tiago Ramires, Catarina Silva, Carolina Roriz, Rui Morais, Patrícia Patrício, André Luiz Pinto, Lurdes Santos, Vasco Costa, Pedro Cunha, Celina Gonçalves, Sandra Nunes, João Camões, Diana Adrião, Ali S. Omrani, Abdurrahmaan Suei elbuzidi, Bara Mahmoud Al qudah, Abdel Rauof Akkari, Mohamed Alkhatteb, Anas Baiou, Ahmed Husain, Mohamed Alwraidat, Ibrahim Abdulsalam Saif, Dana Bakdach, Amna Ahmed, Mohamed Aleef, Awadh Bintaher, Cristina Petrisor, Е. А. Попов, Ksenia Popova, Mariia Dementienko, Boris Teplykh, Liubov Davydova, Belskii Vladislav, Elena Neporada, Ivan Zverev, Svetlana Meshchaninova, Д. В. Соколов, Elena Gavrilova, И. В. Шлык, Igor Poliakov, М. Vlasova, Ohoud Aljuhani, Amina Alkhalaf, Felwa Bin Humaid, Yaseen M. Arabi, Ahmed Kuhail, Omar Elrabi, Madihah E. Ghannam, Ng Teng Fong, Amit Kansal, Vui Kian Ho, Jensen Ng, Raquel Rodrígez García, Xiana Taboada Fraga, Ma del Pilar García-Bonillo, Antonio Padilla‐Serrano, Marta Cuadrado, Carlos Ferrando, Ignacio Catalan-Monzon, Fernando Frutos–Vivar, Jorge Jiménez, Carmen Rodríguez-Solis, Enric Franquesa-Gonzalez, Guillermo Pérez Acosta, Luciano Santana-Cabrera, Juan Pablo Aviles Parra, Francisco Muñoyerro Gonzalez, Maria del Carmen Lorente Conesa, Ignacio Yago Martínez Varela, Orville Victoriano Baez Pravia, Carlos Munoz de Cabo, A Ioan, César Pérez–Calvo, Arnoldo Santos, Ane Abad-Motos, Javier Ripollés‐Melchor, Belén Civantos Martin, Santiago Teruel, Juan Higuera Lucas, Aaron Blandino Ortíz, Raúl de Pablo, Jesús Emilio Barrueco-Francioni, Lorena Forcelledo Espina, José M. Bonell-Goytisolo, Iñigo Salaverria, Emilio Rodríguez‐Ruiz, Virginia Hidalgo Valverde, Patricia Jimeno Cubero, F. Árbol Linde, Nieves Cruza Leganes, Juan Maria Romeu, Pablo Concha, José Ángel Berezo-García, Virginia Fraile, Cristina Cuenca-Rubio, David Pérez-Torres, Ainhoa Serrano, Clara Valero, Andrea Ortiz Suñer, Leire Larrañaga, Noemi Legaristi, Gerardo Ferrigno, Safa Khlafalla, Rosita Bihariesingh-Sanchit, Hallands Sjukhus, Frank Zoerner, Jonathan Grip, Kristina Kilsand, Johan Mårtensson, Jonas Österlind, Akademiska Sjukhuset, Magnus von Seth, Västerviks Sjukhus, Johan Berkius, Samuele Ceruti, Andrea Glotta, Şeval İzdeş, İşil Özkoçak Turan, Ahmet Cosar, Burçin Halaçlı, Necla Dereli, Mehmet Birhan Yılmaz, Türkay Akbaş, Gülseren Elay, Selin Eyüpoğlu, Yelíz Bílír, Kemal Tolga Saraçoğlu, Ebru Kaya, Ayça Sultan Şahin, Pervin Korkmaz Ekren, Tuğçe Mengi, Kezban Özmen Süner, Yakup Tomak, Ahmet Eroğlu, Asad Alsabbah, Katie Hanlon, Kevin Gervin, Sean McMahon, Samantha Hagan, C.V. Higenbottam, Randeep Mullhi, Lottie Poulton, Tomasz Torliński, Allen Gareth, Nick Truman, Gopal Vijayakumar, Chris Hall, Lenka Cagova, Nicola Jones, Sam Graham, Nicole Robin, Amanda Cowton, Adrian Donnelly, Melanie Kent, Carole Boulanger, Zoë Campbell, Elizabeth Potter, Natalie Duric, Tamás Szakmány, Royal Brompton, Orinta Kviatkovske, Nandor Marczin, Caroline Ellis, Rajnish Saha, Chunda Sri-Chandana, John N. Allan, Lana Mumelj, Harish Venkatesh, Vera Nina Gotz, Anthony Cochrane, Barbara Ficial, Shruthi Kamble, Nuttha Lumlertgul, Christopher Oddy, Susan Jain, Giulia Beatrice Crapelli, Aikaterini Vlachou, David B.K. Golden, Sweyn Garrioch, Jeremy Henning, Gupta Loveleena, Miriam Davey, Lina Grauslyte, Erika Šalčiūtė-Šimėnė, Martin Cook, Danny Barling, P. Broadhurst, Sarah Purvis, Michael Spivey, Benjamin Shuker, Irina Grecu, Daniel Harding, James T. Dean, Nathan D. Nielsen, Sama Al-Bayati, Mohammed Al‐Sadawi, Mariane Charron, Peter Stubenrauch, Jairo Santanilla, Catherine Wentowski, Dorothea Rosenberger, Polikseni Eksarko, Randeep S. Jawa
89Citations signalées — pas une note de qualité
51Institutions déclarées
14Pays d’affiliation déclarés
Résumé fourni par la source
PURPOSE: To accommodate the unprecedented number of critically ill patients with pneumonia caused by coronavirus disease 2019 (COVID-19) expansion of the capacity of intensive care unit (ICU) to clinical areas not previously used for critical care was necessary. We describe the global burden of COVID-19 admissions and the clinical and organizational characteristics associated with outcomes in critically ill COVID-19 patients. METHODS: Multicenter, international, point prevalence study, including adult patients with SARS-CoV-2 infection confirmed by polymerase chain reaction (PCR) and a diagnosis of COVID-19 admitted to ICU between February 15th and May 15th, 2020. RESULTS: 4994 patients from 280 ICUs in 46 countries were included. Included ICUs increased their total capacity from 4931 to 7630 beds, deploying personnel from other areas. Overall, 1986 (39.8%) patients were admitted to surge capacity beds. Invasive ventilation at admission was present in 2325 (46.5%) patients and was required during ICU stay in 85.8% of patients. 60-day mortality was 33.9% (IQR across units: 20%-50%) and ICU mortality 32.7%. Older age, invasive mechanical ventilation, and acute kidney injury (AKI) were associated with increased mortality. These associations were also confirmed specifically in mechanically ventilated patients. Admission to surge capacity beds was not associated with mortality, even after controlling for other factors. CONCLUSIONS: ICUs responded to the increase in COVID-19 patients by increasing bed availability and staff, admitting up to 40% of patients in surge capacity beds. Although mortality in this population was high, admission to a surge capacity bed was not associated with increased mortality. Older age, invasive mechanical ventilation, and AKI were identified as the strongest predictors of mortality.
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Contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Clinical and organizational factors associated with mortality during the peak of first COVID-19 wave: the global UNITE-COVID study
- Date Crossref
- 21/05/2022
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude et ne compte pas comme une seconde source scientifique indépendante.
Institutions déclarées
Une affiliation ne permet pas de déduire la nationalité d’un auteur.
Sujets associés
COVID-19 Clinical Research StudiesSepsis Diagnosis and TreatmentCOVID-19 and healthcare impacts