Breakthrough COVID-19 Infections in the US: Implications for Prolonging the Pandemic
Rattachement africain : us. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
The incidence of COVID-19 breakthrough infections-an infection that occurs after you have been vaccinated-has increased in frequency since the Delta and now Omicron variants of the SARS-CoV-2 coronavirus have become the dominant strains transmitted in the United States (US). Evidence suggests that individuals with breakthrough infections, though rare and expected, may readily transmit COVID-19 to unvaccinated populations, posing a continuing threat to the unvaccinated. Here, we examine factors contributing to breakthrough infections including a poor immune response to the vaccines due to the fact of advanced age and underlying comorbidities, the natural waning of immune protection from the vaccines over time, and viral variants that escape existing immune protection from the vaccines. The rise in breakthrough infections in the US and how they contribute to new infections, specifically among the unvaccinated and individuals with compromised immune systems, will create the need for additional booster vaccinations or development of modified vaccines that directly target current variants circulating among the general population. The need to expedite vaccination among the more than 49.8 million unvaccinated eligible people in the US is critical.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Breakthrough COVID-19 Infections in the US: Implications for Prolonging the Pandemic
- Date Crossref
- 11/05/2022
- Éditeur
- MDPI AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Meharry Medical College Department of Family & Community Medicine pays non établi dans la noticeUniversité ou école supérieure
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Tennessee Department of Health pays non établi dans la noticeOrganisme public
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School of Medicine Department of Microbiology pays non établi dans la noticeUniversité ou école supérieure
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Office of Health Disparities Elimination pays non établi dans la noticeInstitution
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School of Graduate Studies and Research pays non établi dans la noticeUniversité ou école supérieure
Department of Family & Community Medicine — Meharry Medical College, Tennessee Department of Health et Department of Microbiology — School of Medicine, avec 2 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.