HIT Poster session 1P154Preclinical diastolic dysfunction is related to impaired endothelial function in patients with chronic kidney diseaseP155Early detection of left atrial and left ventricular abnormalities in hypertensive and obese womenP156Right ventricle preserved systolic function irrespective of right ventricular hypertrophy and disease severity in anderson fabry diseaseP157Left atrial volume and function in patients undergoing percutaneous mitral valve repairP158Impact of left ventricular dysfunction on outcomes of patients undergoing direct TAVI with a self-expanding bioprosthesisP159Anatomic Doppler spectrum – retrospective spectral tissue Doppler from ultra high frame rate tissue Doppler imaging for evaluation of tissue deformationP160Phasic dynamics of ischaemic mitral regurgitation after primary coronary intervention in acute myocardial infarction: serial echocardiographic assessment from emergency room to long-term follow-upP161Reproducibility of 3DE RV volumes - novel

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Background: Many of the proposed parameters for the assessment of diastolic function are load-dependent and equally susceptible to variability in interpretation. In contrast to 2D and Doppler analysis, speckle tracking echocardiography (STE) is free from subjective interpretations of myocardial motion and is independent of the insonation angle. The aim of the study was to evaluate left ventricular (LV) myocardial diastolic deformation in patients with chronic aortic regurgitation (AR) with preserved LV systolic function by STE and relationship with conventional diastolic parameters. Methods: Middle aged men with moderate or severe chronic AR were divided into two groups with normal LV diastolic function (n=6) and with diastolic dysfunction (n=9). Age, sex-matched control subjects (n=19) were included in the study. A standard echocardiography was performed. The peak of early (E) and late diastolic filling (A) velocities, E deceleration time (DT), the mean of mitral annular lateral and septal early diastolic velocities (e’) and the E/e’ ratio were assessed. LV diastolic longitudinal, circumferential and radial global strain rate (Sr) (early diastolic and late diastolic) weremeasured off–line by 2D STE.Results: Patients with diastolic dysfunction had significantly reduced early diastolic longitudinal and circumferential global Sr compared to controls (1,18+0,19 vs. 1,42+0,25 1/s and 1,64+0,36 vs. 2,05+0,32 1/s respectively, p,0,05) and early diastolic longitudinal global SR was reduced compared to patients with normal diastolic function (1,18+ 0,19 vs. 1,66+0,40 1/s, p,0,05). The LV early diastolic longitudinal and circumferential global Sr between patients with normal diastolic function and controls were comparable. The late diastolic longitudinal and circumferential global Sr of LV in both patients groups were decreased, but significantly in patients with preserved diastolic function compared to controls (0,85+0

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