Neutrophil Activation in Smokers
Rattachement africain : us. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Smoking and elevated leukocyte counts are risk factors for cardiovascular disease. Experimental studies suggest that leukocyte activation may be a requirement for certain cardiovascular complications. Clinical studies have demonstrated activated leukocytes in the peripheral blood of stroke victims. Accordingly, neutrophil activation in unseparated whole blood of smokers as well as naive neutrophils of non-smokers exposed to plasma of smokers was investigated. Both spontaneous superoxide formation as determined by nitroblue tetrazolium reduction, as well as pseudopod formation, are significantly elevated in autologous neutrophils of smokers. The surface expression of CD18 and L-selectin on autologous circulating neutrophils of smokers is not significantly different from non-smoker controls. In contrast, incubation of naive neutrophils with smoker plasma leads to significantly higher levels of superoxide formation, pseudopod formation, and L-selectin shedding, compared with non-smoker plasma, suggesting that the plasma of smokers contains a transferable factor which causes leukocyte activation. The results indicate that analysis of blood samples from large peripheral veins may not accurately reflect leukocyte activation in the circulation since activated leukocytes have a higher probability to be trapped in the microcirculation.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Neutrophil Activation in Smokers
- Date Crossref
- 01/04/1996
- Éditeur
- SAGE Publications
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of California San Diego Department of Bioengineering and Institute for Biomedical Engineering pays non établi dans la noticeUniversité ou école supérieure
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La Jolla Bioengineering Institute pays non établi dans la noticeOrganisation à but non lucratif
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Scripps Research Institute Department of Molecular and Experimental Medicine pays non établi dans la noticeOrganisation à but non lucratif
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Journal: pays non établi dans la noticeInstitution
Department of Bioengineering and Institute for Biomedical Engineering — University of California San Diego, La Jolla Bioengineering Institute et Department of Molecular and Experimental Medicine — Scripps Research Institute, avec 1 autre affiliation.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.