A logical basis for age matching in organ transplantation: studies of recipient renal function in relation to donor age

Le résumé fourni par la source

The ever rising demand for renal transplantation has led to an increased use of older (> 50 years) organ donors [9]. Previous studies have shown that donor-to-recipient age difference is an independent risk factor for allograft survival [3]. A recent multicentre study of 6397 first cadaver renal transplants showed that, where donors are more than 5 years older than the recipient, there is significantly impaired graft survival [11]. The mechanism of this effect is unclear, but it has been suggested that age-related donor factors may influence subsequent graft function. Pathological studies have shown that native kidneys acquire specific histological (i. e. glomerulosclerosis, interstitial fibrosis) and functional defects in a linear fashion related to increasing age [1, 5]. Whilst graft loss may be seen as the worst outcome from using older donors, impaired function leading to shortened half-life may also occur. Recipients of kidneys from donors > 50 years of age also have a significantly higher creatinine than those from donors < 50 years of age [3]. A study was therefore undertaken to investigate in greater detail the effect of age on the function of donor kidneys in their respective recipients.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.