N-Chlorosuccinimide

Le résumé fourni par la source

[128-09-6] C4H4ClNO2 (MW 133.53) InChI = 1S/C4H4ClNO2/c5-6-3(7)1-2-4(6)8/h1-2H2 InChIKey = JRNVZBWKYDBUCA-UHFFFAOYSA-N (electrophilic α-chlorination of sulfides, sulfoxides, and ketones; preparation of N-chloroamines) Alternative Names: 1-chloro-2,5-pyrrolidinedione; NCS. Physical Data: mp 144–146 °C. Solubility: sol H2O; sl sol CCl4, benzene, toluene, AcOH; insol ether. Form Supplied in: white powder or crystals having a weak odor of chlorine when pure; widely available. Purification: the commercial reagent acquires a light yellow color and a rather strong odor of chlorine after long storage but is easily recrystallized from acetic acid: rapidly dissolve 200 g of impure sample in 1 L preheated glacial AcOH at 65–70 °C (3–5 min); cool to 15–20 °C to effect crystallization; filter through a Buchner funnel and wash the white crystals once with glacial AcOH and twice with hexane; dry in vacuo (>85% recovery). Analysis of Reagent Purity: the standard iodide–thiosulfate titration method is suitable. Handling, Storage, and Precautions: store under refrigeration and protect from moisture; acutely irritating solid, with toxic effects similar to those of the free halogens; avoid inhalation; use an efficient fume hood; perform all operations as rapidly as possible to avoid extensive decomposition of the reagent.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.