Predictors of health-related quality of life in Chinese patients receiving treatment for neovascular age-related macular degeneration: A Prospective Longitudinal study

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Abstract Objectives Age-related macular degeneration (AMD) is currently the leading cause of irreversible visual impairment in developed countries and seriously affect the health-related quality of life (HRQoL) of patients. However, the majority of the researches in this area employ cross-sectional design, and the longitudinal researches investigating changes in HRQoL and influence factors are limited. The aim of the study was to use longitudinal study design to investigate descriptive trends in HRQoL and predictive factors in Chinese AMD patients receiving treatment of vascular endothelial growth factor inhibitors (anti-VEGF) at baseline and follow-ups.Methods A sample of 142 AMD patients from the outpatient clinic of the Southwest Eye Hospital, a tertiary major hospital in the southwest of China. Each patient completed a self-administered questionnaire assessing demographics,clinical features, HRQoL, depression, anxiety, coping style, social support and self-efficacy at baseline, 1, 3, 6 and 12 months’ follow-up.Results The total score of HRQoL was fluctuated with the highest score at 6 months follow-up and the lowest score at baseline. Multivariable linear regression showed the predictors of HRQoL are best-corrected visual acuity (BCVA), income, depression andvisual acuity (VA) of the treated eye at baseline; BCVA, income and depression at 1 month follow-up; duration, area of residence, gender, VA of the treated eye, BCVA, income, anxiety, social support, self-efficacy, depression at 3 months follow-up; gender, BCVA, income, anxiety, social support, self-efficacy, depression, negative coping and positive coping at 6 months follow-up; BCVA, social support, self-efficacy and depression at 12 months follow-up.Conclusions The HRQoL and its predictive factors in Chinese AMD patients receiving treatment of anti-VEGF were fluctuated over time. It is suggested that the medical staff should get more information when planning precise care for improving HRQoL of the patients.

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