The Fruit Fly Brain Observatory: from structure to function
Rattachement africain : us, gb, tw. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Summary The Fruit Fly Brain Observatory (FFBO) is a collaborative effort between experimentalists, theorists and computational neuroscientists at Columbia University, National Tsing Hua University and Sheffield University with the goal to (i) create an open platform for the emulation and biological validation of fruit fly brain models in health and disease, (ii) standardize tools and methods for graphical rendering, representation and manipulation of brain circuits, (iii) standardize tools for representation of fruit fly brain data and its abstractions and support for natural language queries, (iv) create a focus for the neuroscience community with interests in the fruit fly brain and encourage the sharing of fruit fly brain structural data and executable code worldwide. NeuroNLP and NeuroGFX, two key FFBO applications, aim to address two major challenges, respectively: i) seamlessly integrate structural and genetic data from multiple sources that can be intuitively queried, effectively visualized and extensively manipulated, ii) devise executable brain circuit models anchored in structural data for understanding and developing novel hypotheses about brain function. NeuroNLP enables researchers to use plain English (or other languages) to probe biological data that are integrated into a novel database system, called NeuroArch, that we developed for integrating biological and abstract data models of the fruit fly brain. With powerful 3D graphical visualization, NeuroNLP presents a highly accessible portal for the fruit fly brain data. NeuroGFX provides users highly intuitive tools to execute neural circuit models with Neurokernel, an open-source platform for emulating the fruit fly brain, with full data support from the NeuroArch database and visualization support from an interactive graphical interface. Brain circuits can be configured with high flexibility and investigated on multiple levels, e.g., whole brain, neuropil, and local circuit levels. The FFBO is publicly available and accessible at http://fruitflybrain.org from any modern web browsers, including those running on smartphones.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- The Fruit Fly Brain Observatory: from structure to function
- Date Crossref
- 14/12/2016
- Éditeur
- openRxiv
- Type
- posted-content
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Columbia University Department of Electrical Engineering pays non établi dans la noticeUniversité ou école supérieure
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University of Sheffield Department of Automatic Control & Systems Engineering pays non établi dans la noticeUniversité ou école supérieure
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National Tsing Hua University Brain Research Center pays non établi dans la noticeUniversité ou école supérieure
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Kaohsiung Medical University Department of Biomedical Science and Environmental Biology pays non établi dans la noticeUniversité ou école supérieure
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University of California San Diego Kavli Institute for Brain and Mind pays non établi dans la noticeUniversité ou école supérieure
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Genomics Research Center pays non établi dans la noticeStructure de recherche
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Institute of Physics pays non établi dans la noticeStructure de recherche
Department of Electrical Engineering — Columbia University, Department of Automatic Control & Systems Engineering — University of Sheffield et Brain Research Center — National Tsing Hua University, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.