Ovomucoid-specific IgD increases in children who naturally outgrow egg allergy
Rattachement africain : jp, gb. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Background: The majority of egg-allergic children outgrow hypersensitivity against heated egg and then raw egg over time. The roles of ovomucoid (OVM)- and ovalbumin (OVA)-specific IgD in children who naturally outgrow egg allergy are uncertain. We investigated whether specific IgD to egg white (EW), OVM, and OVA correlate with allergen-specific IgE and can predict the development of immune tolerance to egg allergens. Methods: The tolerated doses of cooked egg white, which were determined by oral food challenge and/or an episode of accidental ingestion and corresponding specific IgE, IgG4 and IgD levels were evaluated in 57 children with egg allergy and 23 non-egg allergic children. Results: Patients avoiding all forms of egg had lower EW-, OVM-, and OVA-specific IgD and IgG4 than those partially avoiding egg, those that had outgrown egg allergy, and non-egg allergic children. The ratio of OVM-specific IgD to OVA-specific IgD increased depending on the ingestible amounts of boiled EW, whereas the ratio of OVM-specific IgG4 to OVA-specific IgG4 did not change. Receiver operating curve analysis revealed that the ratio of OVM-specific IgE to OVM-IgD was the best index to discriminate intolerant from tolerant egg-allergic patients. Conclusion: The production of OVM-specific IgD differs from OVM-specific IgG4 as children naturally outgrow egg allergy. The ratio of OVM-specific IgE to OVM-specific D is useful in distinguishing egg-sensitized patients with clinically reactive egg allergy from those who naturally outgrow egg allergy.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Ovomucoid-specific IgD increases in children who naturally outgrow egg allergy
- Date Crossref
- 30/03/2022
- Éditeur
- Wiley
- Type
- posted-content
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of Fukui pays non établi dans la noticeUniversité ou école supérieure
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Fukui Red Cross Hospital . Department of Pediatrics pays non établi dans la noticeÉtablissement de santé
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Municipal Tsuruga Hospital . Department of Pediatrics pays non établi dans la noticeÉtablissement de santé
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City Hospital pays non établi dans la noticeÉtablissement de santé
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Ohta Nishinouchi Hospital pays non établi dans la noticeÉtablissement de santé
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Faculty of Medical Sciences . Department of Pediatrics pays non établi dans la noticeUniversité ou école supérieure
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Ohtaki Hospital . Department of Pediatrics pays non établi dans la noticeÉtablissement de santé
University of Fukui, . Department of Pediatrics — Fukui Red Cross Hospital et . Department of Pediatrics — Municipal Tsuruga Hospital, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.