Superoxide dismutase 6 is required during metamorphosis for the development of properly movable legs in Tribolium castaneum
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Le résumé fourni par la source
The body form of holometabolous insects dramatically transforms from larval to adult stages during metamorphosis that occurs in the pupal stage. The larval disorganization and then new adult tissues are built up at this time. In motoneuron, larval neuronal cells degenerate, and new adult neurons are remodeled. Finally, adult neurons reconnect to new adult muscles. However, the factors that control metamorphosis have not yet been fully elucidated. Here, we show that an antioxidant enzyme, Tribolium castaneum superoxide dismutase 6 (TcSOD6), is secreted into the haemolymph and is required for proper movable legs during metamorphosis. TcSOD6 has a unique domain architecture and is mainly expressed in the pupal stage. The depletion of TcSOD6 expression in the pupa inhibits normal axon development and results in adults that display dysfunctional leg motions, suggesting that SOD6 expression is required for the development of properly movable legs. Therefore, we speculate that TcSOD6 might participate in some of the processes for larval neurons to be remodelled to new adult functions in the legs during metamorphosis, providing new insight into the evolution of SOD functions.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Superoxide dismutase 6 is required during metamorphosis for the development of properly movable legs in Tribolium castaneum
- Date Crossref
- 27/04/2022
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Tokyo University of Agriculture and Technology Institute of Global Innovation Research pays non établi dans la noticeUniversité ou école supérieure
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Institute of Global Innovation Research (Tokyo University of Agriculture and Technology) pays non établi dans la noticeStructure de recherche
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Chonnam National University Department of Applied Biology pays non établi dans la noticeUniversité ou école supérieure
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Kansas State University Department of Biochemistry and Molecular Biophysics pays non établi dans la noticeUniversité ou école supérieure
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Department of United Graduate School of Agricultural Science pays non établi dans la noticeUniversité ou école supérieure
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Graduate School of Agriculture Department of Science of Biological Production pays non établi dans la noticeUniversité ou école supérieure
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Graduate School of Bio-Applications and System Engineering Cooperative Major in Advanced Health Science pays non établi dans la noticeUniversité ou école supérieure
Institute of Global Innovation Research — Tokyo University of Agriculture and Technology, Institute of Global Innovation Research (Tokyo University of Agriculture and Technology) et Department of Applied Biology — Chonnam National University, avec 4 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.