Synthetic cannabinoids affect the expression of autophagic mediators ATG5, BECLIN-1, RAB7A and LC3 in brain-derived NG108-15 cells

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using an organic solvent while the liquid phase was preconcentrated by solid phase extraction using OASIS® MCX cartridges.Both matrices were derivatized and further analysed by GC-MS.Results: The method was validated according to the International Conference on Harmonization (ICH), considering the following parameters: selectivity, linearity, limit of detection (LOD), limit of quantification (LOQ), accuracy, precision, and recovery [5].For both matrices, raw sewage and the SPM, the method was linear (R2 > 0.99 and R2>98 respectively) and LOQs varied between 10 ng/L to 20 ng/L.Conclusion: The validated method will allow to assess the consumption patterns at community level, as well as occurrence, spatial distribution, and the EF of the target chiral PADs. R e s u m o s d a s C o m u n i c a ç õ e s e m P o s t e r

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