Accès ouvert déclaré
2022
article
Autoimmune disease and COVID-19: a multicentre observational study in the United Kingdom
Deepa J. Arachchillage, Indika Rajakaruna, Charis Pericleous, Phillip L.R. Nicolson, Amanda Dell, Angela Hall, Anna Roynon, Anne Héron, Claire Price, C. I. Westacott, Debra Barnett, Gail Marshall, Gemma Hodkinson, Georgia Mallison, Grace Okoro, Joshua Gwatkin, Kirstin Davies, Lucy Shipp, Maxine Nash, Rhian Hughes, Rina Mardania, Sarah Lewis Sean Cutler, Caroline Allan, Atiqa Miah, Dide Okaygun, Dan Hart, Faith Dzumbunu, James E. Leveson, Karen Torre, Louise Taylor, Priyanka Raheja, Sara Mamsa, Tasnima Ferdousi, Angharad Everden, Alice Ngumo, Doaa Ahmed, Efstathia Venizelou, James Herdman, Janice Carpenter, Konrad Bartkiewicz, Rebecca E. Cash, Renu Riat, Abigail Downing, Ana Guerrero, Astrid Etherington, Chapa Gamage, D. H. P. S. Gunasekara, Lee M. Morris, Raza Alikhan, Rebecca Cloudsdale, Samya Obaji, Stuart Cunningham, Sylvain Ndjombo, Amanda Cowton, Ami Wilkinson, Andrea Kay, Anne Sebakungu, Anne Thomson, Clare Brady, Dawn Egginton, Ellen Brown, Gill Rogers, Hannah Plaschkes, Jacqui Jennings, Julie O’Brien, Julie Temple, Kathryn Potts, Kimberly Stamp, Kelly Postlethwaite, Louise Duncan, Margaret Randall, Mark Birt, Melanie Kent, Philip Mounter, Shelly Wood, Nicola Hewitson, Noreen Kingston, Susan Wadd, Sarah McAuliffe, Stefanie Hobson, Susan Riley, Suzanne Naylor, Vicki Atkinson, Bethan Deacon, Carla Pothecary, Caroline Hamilton, Ceri Lynch, C Evenden, Deborah Jones, Ellie Davies, Felicity Page, Gareth Kennard-Holden, John Gavin, Joanne Pugh, Joelle Pike, Justyna Mikusek, Kevin Agravante, Kia Hancock, Lauren Geen, M. Agnes van Rees, Natalie Stroud, Amanda Grahamslaw, Amanda Sanderson, Beverley McClelland, Caitlin Barry, Elaine Siddle, Lorraine Pearce, Lucy Blackwell, Maria Bokhari, Maureen Armstrong, Wendy Stoker, W McCormick, Caterina Vlachou, Ben Garfield, Mihaela Gaspar, Maurizio Passariello, Paolo Bianchi, Stéphane Ledot, Aileen Madlin, Kerrianne Everard, Khushboo Panwar, Natasha Beacher, Niamh Cole, Sarah Mangles, Tamara Everington, Udaya Reddy, Alka Shah, Anna Weatherill, Anthi Maropoulou, Bhagya Herath, Billy Hopkins, Camelia Vladescu, Caroline Ward, Christina Crossette-Thambiah Donna Copeland, Emily Pickford, Gaurika Kapoor, Isabella Lo, John A. Kilner, Keith Boland, Melanie Almonte, Neil Simpson, Niamh Bohnacker, Omolade Awomolo, Roochi Trikha, Samina Hussain, Serah Duro, Sophie Kathirgamanathan, Y. Needham, Y. H. Hui, Zainab Alashe, Adrienne Abioye, Aileen Miranda, C.C. Obiorah, Cynthia Dzienyo, Hasina Mangal, Hernan Zorraquino, Lara N. Roberts, Mariusz Racz, Mark R. Johnson, Rachel Ryan, Tamara Swales, T Taran, Zoe Renshaw, Alexander Langridge, B. J. K. Evans, Callum Weller, Claire Judd, Douglas Jerry, Euan Haynes, Fatima Jamil, Ian McVittie, John Hanley, Julie Parker, Kayleigh Smith, Keir Pickard, Laura Kennedy, Meghan Acres, Mikaela Wiltshire, N. Padma Ramachandran, Paul McAlinden, Paula Glancy, Smeera Nair, Tarek Almugassabi, Thomas Jarvis, Amanda Coutts, Andrew Laurie, Deborah Owen, Ian Scott, Jamie G. Cooper, Leia Kane, Lucy Sim, Mahmoud A. E. Abdelrahman, Victoria Poulton, Jessica Griffin, Ria Markwell, Suzanne Docherty, Alexander Brown, Barbara M. Cooper, Beverley Wilkinson, Diane Armstrong, Grace Fryer, Jane Gregory, Katherine Davidson, Melanie Clapham, Nicci Kelsall, P. Nicholls, Rachel Hardy, Roderick Oakes, Rosemary Harper, Theresa Cooper, Una Poultney, Zoe Saunders, Alex Ramshaw, Alison Chilvers, Barbara Jean Campbell, Carol Adams, Claire Riley, Deborah Wilson, H M Wardle, Jill Deane, Jill Skelton, Julie Quigley, Leigh Pollard, Liz Baker, Lynda Poole, Maria Weetman, Michele Clark, Nini Aung, Rachel Taylor, Sarah Rowling, Sarah Purvis, Vicky Collins, Amy Shenfine, Catherine Ashbrook-Raby, Charlotte Bomken, Claire Walker, Faye Cartner, Helen Campbell, Jane Luke, Jessica Reynolds, Mari Kilner, Laura Winder, Lisa G. Gallagher, Nicola McLarty, Sandra Robinson, Steve Dodds, Toni Hall, Victoria Wright, Agnes Eordogh, Alexandros Rampotas, Anna Maria Sanigorska, Christopher Deane, Kristine Santos, Olivia Lecocq, Rochelle Lay, Simon Fletcher, Anna Tarnakina, Aniqa Tasnim, Anja Drebes, C. Bousoño García, Elsa Aradom, María Alexandra Pesántez Peralta, Michaella Tomlin, Pratima Chowdary, Ramona Georgescu, Suluma Mohamed, Upuli Dissanayake, Carol A. Powell, James Doolan, Jessica Kenworthy, Joanne Bell, Lewis Jones, Mikiko Wilkinson, Rebecca Shaw, Ryan Robinson, Saman Mukhtar, Shane D'Souza, Tina Dutt, Tracy Stocks, Joshua Wade, Lenka Cagova, Maksym Kovzel, Rachel Jooste, Alison Delaney, Claire Mapplebeck, Alycon Walker, Andrea Watson, Andrew Vaux, Asia Sawar, Carol Hannaway, Charlotte Jacobs, Claire Elliot, Claire Elliott, Craig Mower, Daiana Ferro, Emanuela Mahmoud, G. Laidlaw, Julie Potts, Keith Harland, Laura Munglani, Lauren Fall, Leanne J. Murray, Lesley K. Harris, Lisa Wayman, Lisa Westwood, Louisa Watson, Lynne Naylor, Matthew Siddaway, Paula J. Robson, Rita Mohan, Sarah Essex, Sara Griffiths, Steven Liggett, Andreia Valente, Rashid Kazmi, Ruth Kirby, Sarah Bowmer, Yanli Li, Alice Longe, Amy Bamford, Anand Lokare, Andrew McDarby, Aneta Drozd, Cathy Stretton, Catia Mulvihill, Charlotte Ferris, Christopher McGhee, Claire McNeill, Colin Bergin, Daniella Lynch, Fionnuala Lenehan, G Gilleran, Gillian Lowe, Graham McIlroy, Helen Jenner, Helen Shackleford, Isma Younis, Jaspret Gill, Jimmy Musngi, Joanne Dasgin, Joanne Gresty, J Nyaboko, J. Mushtari Begum, Katerine Festejo, Katherine Lucas, Katie Price, Khushpreet Bhandal, Kristina Gallagher, Kyriaki Tsakiridou, Lauren Cooper, Louise Wood, Lulu Amutike, Marie Thomas, Marwan Kwok, Melanie E. M. Kelly, Michelle Bates, Nafeesah Haider, Oliver Topping, Rachel L. Smith, R. Joseph, Salma Kadiri, Samantha Caddick, Samuel J. Harrison, Shereef Elmoamly, Stavroula Chante, Sumaiyyah Gauhar, S. M. Ashraf, Tabinda Kharodia, Zhane Peterkin, Isgro Graziella, Hakeem Yusuff, David Sutton, Ian J. Massey, Jade Di-Silvestro, Joanne Hiden, Mia Johnson, Richard J. Buka, Claire Lentaigne, Jackie Wooding, Nicola Crosbie, Ana Alvaro, Emma Drašar, Elen Roblin, Georgina Santiapillai, Kathryn Simpson, Kayleigh Gilbert, Yanrong Jiang, Zara Sayar, Zehra'a Al-Khafaji
15Citations signalées — pas une note de qualité
7Institutions déclarées
2Pays d’affiliation déclarés
Résumé fourni par la source
OBJECTIVE: To establish the demographic characteristics, laboratory findings and clinical outcomes in patients with autoimmune disease (AD) compared with a propensity-matched cohort of patients without AD admitted with COVID-19 to hospitals in the UK. METHODS: This is a multicentre observational study across 26 NHS Trusts. Data were collected both retrospectively and prospectively using a predesigned standardized case record form. Adult patients (≥18 years) admitted between 1 April 2020 and 31 July 2020 were included. RESULTS: Overall, 6288 patients were included to the study. Of these, 394 patients had AD prior to admission with COVID-19. Of 394 patients, 80 patients with SLE, RA or aPL syndrome were classified as severe rheumatologic AD. A higher proportion of those with AD had anaemia [240 (60.91%) vs 206 (52.28%), P = 0.015], elevated LDH [150 (38.08%) vs 43 (10.92%), P < 0.001] and raised creatinine [122 (30.96%) vs 86 (21.83%), P = 0.01], respectively. A significantly higher proportion of patients with severe rheumatologic AD had elevated CRP [77 (96.25%) vs 70 (87.5%), P = 0.044] and LDH [20 (25%) vs 6 (7.5%), P = 0.021]. Patients with severe rheumatologic AD had significantly higher mortality [32/80 (40%)] compared with propensity matched cohort of patients without AD [20/80 (25%), P = 0.043]. However, there was no difference in 180-day mortality between propensity-matched cohorts of patients with or without AD in general (P = 0.47). CONCLUSIONS: Patients with severe rheumatologic AD had significantly higher mortality. Anaemia, renal impairment and elevated LDH were more frequent in patients with any AD while elevated CRP and LDH were more frequent in patients with severe rheumatologic AD both of which have been shown to associate with increased mortality in patients with COVID-19.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Autoimmune disease and COVID-19: a multicentre observational study in the United Kingdom
- Date Crossref
- 04/04/2022
- Éditeur
- Oxford University Press (OUP)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude et ne compte pas comme une seconde source scientifique indépendante.
Institutions déclarées
Une affiliation ne permet pas de déduire la nationalité d’un auteur.
Sujets associés
COVID-19 Clinical Research StudiesSARS-CoV-2 and COVID-19 ResearchDiabetes and associated disorders