Interest of Procalcitonin Measurement in Children with Cerebral Malaria in Southern Benin
Rattachement africain : Bénin, Nigéria. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Introduction: Cerebral malaria is a major complication of the Plasmodium falciparum infection with a high case fatality rate. The objective of this study was to determine the relationship between cerebral malaria and high serum procalcitonin (PCT) level in children. Method: This was a prospective descriptive and analytical cohort study conducted over 12 months, on a series of PCT blood tests in children aged 6 months to 15 years old hospitalized for cerebral malaria in the pediatric wards of four hospitals in southern Benin. The cerebral malaria diagnosis was done based on WHO criteria. Blood samples for PCT measurement were collected on admission, 24 hours and 48 hours after the malaria therapy initiation. Student’s test, Pearson’s chi2 test, Fisher’s test and Kruskal-Wallis test were used where appropriate. For all comparisons the difference was significant when p was less than 5%. Results: Sixty-five children were included in the study with a sex ratio of 1.41. The age group of children under 5 years was the most represented, at 57%. PCT levels were high in 92.3% of children at admission, 90.8% at 24 hours and 84.6% at 48 hours. Forty-nine children had a positive clinical outcome while 16 died (24.6%). PCT levels were generally high over the three days of hospitalization, but higher at admission in case of death (p = 0.000). The association between PCT level and parasitemia at admission was significant (p = 0.04). Conclusion: In the view of the results, blood PCT level measured at admission could be predictive of the disease outcome in children with cerebral malaria.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Interest of Procalcitonin Measurement in Children with Cerebral Malaria in Southern Benin
- Date Crossref
- 01/01/2022
- Éditeur
- Scientific Research Publishing, Inc.
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Université Protestante d'Afrique de l'Ouest Bénin (code pays fourni par la source)Université ou école supérieure
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University of Benin Teaching Hospital Nigéria (code pays fourni par la source)Établissement de santé
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Centre National Hospitalier et Universitaire Hubert Koutoukou MAGA Bénin (code pays fourni par la source)Établissement de santé
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Progamme National Contre le Tuberculose Bénin (code pays fourni par la source)Institution
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Departmental Teaching Hospital of Ouémé-Plateau Pediatrics Department Porto-Novo, Bénin (pays nommé en fin d’affiliation)Établissement de santé
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National Teaching Hospital HKM Immunology Unit Cotonou, Bénin (pays nommé en fin d’affiliation)Établissement de santé
Université Protestante d'Afrique de l'Ouest (Bénin), University of Benin Teaching Hospital (Nigéria) et Centre National Hospitalier et Universitaire Hubert Koutoukou MAGA (Bénin), avec 3 autres affiliations. Pays d’affiliation : Bénin, Nigéria.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.