Serological surveillance of healthcare workers to evaluate natural infection- and vaccine-derived immunity to SARS-CoV-2 during an outbreak in Dili, Timor-Leste
Rattachement africain : au, gb, tl, pk. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Background Serosurveillance can be used to investigate the extent and distribution of immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) within a population. Characterisation of humoral immune responses gives insight into whether immunity is infection- or vaccine-derived. Methods A longitudinal study of health care workers (HCWs) in Dili, Timor-Leste, was conducted during vaccine rollout (ChAdOx1) and a concurrent SARS-CoV-2 outbreak. Results A total of 324 HCWs were included at baseline (April-May 2021). Out of those, 32 (9.9%) were seropositive for anti-nucleocapsid protein (anti-N) IgG antibodies, indicating a significant sub-clinical infection among HCWs early in the local outbreak. Follow-up was conducted in 157 (48.5%) participants (July-September 2021), by which time there had been high uptake of vaccination (91.7%), and 86.0% were seropositive for anti-spike protein antibodies. Acquisition of anti-N antibodies was observed in partially vaccinated HCWs (30/76, 39.5%), indicating some post-dose-1 infections. Discussion Serosurveillance of HCWs may provide early warning of SARS-CoV-2 outbreaks and should be considered in non-endemic settings, particularly where there is limited availability/uptake of testing for acute infection. Characterisation of humoral immune responses may be used to assess vaccine impact and coverage. Such studies should be considered in national and international efforts to investigate and mitigate against future emerging pathogens.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Serological surveillance of healthcare workers to evaluate natural infection- and vaccine-derived immunity to SARS-CoV-2 during an outbreak in Dili, Timor-Leste
- Date Crossref
- 01/06/2022
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Charles Darwin University pays non établi dans la noticeUniversité ou école supérieure
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Menzies School of Health Research Global and Tropical Health Division pays non établi dans la noticeOrganisation à but non lucratif
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Imperial College London pays non établi dans la noticeUniversité ou école supérieure
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Universidade da Paz pays non établi dans la noticeUniversité ou école supérieure
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National Centre for Immunisation Research & Surveillance pays non établi dans la noticeStructure de recherche
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World Health Organization - Pakistan pays non établi dans la noticeOrganisme public
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Hospital Nacional Guido Valadares pays non établi dans la noticeÉtablissement de santé
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National Centre for Immunisation Research and Surveillance pays non établi dans la noticeInstitution
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World Health Organisation pays non établi dans la noticeInstitution
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Ministry of Health pays non établi dans la noticeOrganisme public
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Laboratório Nacional de Saúde pays non établi dans la noticeInstitution
Charles Darwin University, Global and Tropical Health Division — Menzies School of Health Research et Imperial College London, avec 8 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.