Successful Pregnancies, Births, and Children Development Following Oocyte Cryostorage in Female Cancer Patients During 25 Years of Fertility Preservation
Rattachement africain : it. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
The preservation of fertility in cancer patients is a crucial aspect of modern reproductive medicine. Amenorrhea and infertility often occur after cancer therapy, worsening the quality of life. Cryopreservation of oocytes in young cancer patients is a therapeutic option for preserving fertility. A prospective study was conducted on 508 cancer patients who underwent oocyte cryopreservation to preserve fertility between 1996 and 2021 including the COVID-19 pandemic period. Patients underwent ovarian stimulation, followed by egg retrieval, and oocytes were cryopreserved by slow freezing or vitrification. Sixty-four thawing/warming cycles were performed. Survival, fertilization, pregnancy, and birth rate over the thawing/warming cycles were obtained. The data were compared with those from a group of 1042 nononcological patients who cryopreserved supernumerary oocytes. An average of 8.8 ± 6.9 oocytes were retrieved per cycle, and 6.1 ± 4.2 oocytes were cryopreserved. With their own stored oocytes, 44 patients returned to attempt pregnancy. From a total of 194 thawed/warmed oocytes, 157 survived (80%). In total, 100 embryos were transferred in 57 transfer/cycles, and 18 pregnancies were achieved. The pregnancy rate per transfer and pregnancy rate per patient were 31% and 41%, respectively. No statistically significant differences were observed between oncological patients and nononcological patients. A total of 15 babies were born from oncological patients. Children born showed normal growth and development. One minor malformation was detected.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Successful Pregnancies, Births, and Children Development Following Oocyte Cryostorage in Female Cancer Patients During 25 Years of Fertility Preservation
- Date Crossref
- 10/03/2022
- Éditeur
- MDPI AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Azienda USL di Bologna pays non établi dans la noticeÉtablissement de santé
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University of Bologna Department of Medical and Surgical Sciences (DIMEC) pays non établi dans la noticeUniversité ou école supérieure
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Infertility and IVF Unit pays non établi dans la noticeInstitution
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Division of Oncologic Gynecology pays non établi dans la noticeInstitution
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Institute of Haematology “Seragnoli” pays non établi dans la noticeStructure de recherche
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Institute of Haematology "Seragnoli" pays non établi dans la noticeStructure de recherche
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Breast Unit pays non établi dans la noticeInstitution
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“Addari” Medical Oncology pays non établi dans la noticeInstitution
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"Addari" Medical Oncology pays non établi dans la noticeInstitution
Azienda USL di Bologna, Department of Medical and Surgical Sciences (DIMEC) — University of Bologna et Infertility and IVF Unit, avec 6 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.