Precursor Quantitation Methods for Next Generation Food Production
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Le résumé fourni par la source
Food is essential for human survival. Nowadays, traditional agriculture faces challenges in balancing the need of sustainable environmental development and the rising food demand caused by an increasing population. In addition, in the emerging of consumers' awareness of health related issues bring a growing trend towards novel nature-based food additives. Synthetic biology, using engineered microbial cell factories for production of various molecules, shows great advantages for generating food alternatives and additives, which not only relieve the pressure laid on tradition agriculture, but also create a new stage in healthy and sustainable food supplement. The biosynthesis of food components (protein, fats, carbohydrates or vitamins) in engineered microbial cells often involves cellular central metabolic pathways, where common precursors are processed into different proteins and products. Quantitation of the precursors provides information of the metabolic flux and intracellular metabolic state, giving guidance for precise pathway engineering. In this review, we summarized the quantitation methods for most cellular biosynthetic precursors, including energy molecules and co-factors involved in redox-reactions. It will also be useful for studies worked on pathway engineering of other microbial-derived metabolites. Finally, advantages and limitations of each method are discussed.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Precursor Quantitation Methods for Next Generation Food Production
- Date Crossref
- 10/03/2022
- Éditeur
- Frontiers Media SA
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Chinese Academy of Sciences pays non établi dans la noticeOrganisme public
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Shenzhen Institutes of Advanced Technology pays non établi dans la noticeStructure de recherche
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Shenzhen Institute of Synthetic Biology pays non établi dans la noticeStructure de recherche
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CAS Key Laboratory of Quantitative Engineering Biology pays non établi dans la noticeStructure de recherche
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Shenzhen Institute of Advanced Technology pays non établi dans la noticeStructure de recherche
Chinese Academy of Sciences, Shenzhen Institutes of Advanced Technology et Shenzhen Institute of Synthetic Biology, avec 2 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.