Dissociation of tau pathology and neuronal hypometabolism within the ATN framework of Alzheimer’s disease

Le résumé fourni par la source

Abstract Alzheimer’s disease (AD) is defined by amyloid (A) and tau (T) pathologies, with T better correlated to neurodegeneration (N). However, T and N have complex regional relationships in part related to non-AD factors that influence N. With machine learning, we assessed heterogeneity in 18 F-flortaucipir vs. 18 F-fluorodeoxyglucose positron emission tomography as markers of T and neuronal hypometabolism (N M ) in 289 symptomatic patients from the Alzheimer’s Disease Neuroimaging Initiative. We identified six T/N M clusters with differing limbic and cortical patterns. The canonical group was defined as the T/N M pattern with lowest regression residuals. Groups resilient to T had less hypometabolism than expected relative to T and displayed better cognition than the canonical group. Groups susceptible to T had more hypometabolism than expected given T and exhibited worse cognitive decline, with imaging and clinical measures concordant with non-AD copathologies. Together, T/N M mismatch reveals distinct imaging signatures with pathobiological and prognostic implications for AD.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.