Temporally dynamic neural correlates of drug cue reactivity, response inhibition, and methamphetamine-related response inhibition in people with methamphetamine use disorder
Rattachement africain : ir, fr, us. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Cue-induced drug craving and disinhibition are two essential components of continued drug use and relapse in substance use disorders. While these phenomena develop and interact across time, the temporal dynamics of their underlying neural activity remain under-investigated. To explore these dynamics, an analysis of time-varying activation was applied to fMRI data from 62 men with methamphetamine use disorder in their first weeks of recovery in an abstinence-based treatment program. Using a mixed block-event, factorial cue-reactivity/Go-NoGo task and a sliding window across the task duration, dynamically-activated regions were identified in three linear mixed effects models (LMEs). Habituation to drug cues across time was observed in the superior temporal gyri, amygdalae, left hippocampus, and right precuneus, while response inhibition was associated with the sensitization of temporally-dynamic activations across many regions of the inhibitory frontoparietal network. Methamphetamine-related response inhibition was associated with temporally-dynamic activity in the parahippocampal gyri and right precuneus (corrected p-value < 0.001), which show a declining cue-reactivity contrast and an increasing response inhibition contrast. Overall, the declining craving-related activations (habituation) and increasing inhibition-associated activations (sensitization) during the task duration suggest the gradual recruitment of response inhibitory processes and a concurrent habituation to drug cues in areas with temporally-dynamic methamphetamine-related response inhibition. Furthermore, temporally dynamic cue-reactivity and response inhibition were correlated with behavioral and clinical measures such as the severity of methamphetamine use and craving, impulsivity and inhibitory task performance. This exploratory study demonstrates the time-variance of the neural activations undergirding cue-reactivity, response inhibition, and response inhibition during exposure to drug cues, and suggests a method to assess this dynamic interplay. Analyses that can capture temporal fluctuations in the neural substrates of drug cue-reactivity and response inhibition may prove useful for biomarker development by revealing the rate and pattern of sensitization and habituation processes, and may inform mixed cue-exposure intervention paradigms which could promote habituation to drug cues and sensitization in inhibitory control regions.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Temporally dynamic neural correlates of drug cue reactivity, response inhibition, and methamphetamine-related response inhibition in people with methamphetamine use disorder
- Date Crossref
- 04/03/2022
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Shiraz University of Technology Department of Electrical and Electronics Engineering pays non établi dans la noticeUniversité ou école supérieure
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University of Tehran pays non établi dans la noticeUniversité ou école supérieure
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Centre Hospitalier Universitaire Amiens-Picardie pays non établi dans la noticeÉtablissement de santé
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Laboratoire de neurosciences fonctionnelles et pathologies pays non établi dans la noticeStructure de recherche
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Université de Picardie Jules Verne pays non établi dans la noticeUniversité ou école supérieure
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Iran University of Medical Sciences Medical Physics Department pays non établi dans la noticeUniversité ou école supérieure
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Tehran University of Medical Sciences Iranian National Center for Addiction Studies (INCAS) pays non établi dans la noticeUniversité ou école supérieure
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Laureate Institute for Brain Research pays non établi dans la noticeStructure de recherche
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Faculty of Medicine pays non établi dans la noticeUniversité ou école supérieure
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University Research Center (CURS) Laboratory of Functional Neuroscience and Pathologies (LNFP) pays non établi dans la noticeUniversité ou école supérieure
Department of Electrical and Electronics Engineering — Shiraz University of Technology, University of Tehran et Centre Hospitalier Universitaire Amiens-Picardie, avec 7 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.